2024-03-29T06:00:07Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02008831
2023-08-03T05:41:27Z
1642838163960:1642838338003
1642838403551:1642838412624
Intravenous Mycobacterium Bovis Bacillus Calmette-Guérin Ameliorates Nonalcoholic Fatty Liver Disease in Obese, Diabetic ob/ob Mice
Inafuku, Masashi
Matsuzaki, Goro
Oku, Hirosuke
open access
Inflammation and immune response profoundly influence metabolic syndrome and fatty acid metabolism. To analyze influence of systemic inflammatory response to metabolic syndrome, we inoculated an attenuated vaccine strain of Mycobacterium bovis Bacillus Calmette–Guérin (BCG) into leptin-deficient ob/ob mice. BCG administration significantly decreased epididymal white adipose tissue weight, serum insulin levels, and a homeostasis model assessment of insulin resistance. Serum high molecular weight (HMW) adiponectin level and HMW/total adiponectin ratio of the BCG treated mice were significantly higher than those of control mice. Hepatic triglyceride accumulation and macrovesicular steatosis were markedly alleviated, and the enzymatic activities and mRNA levels of lipogenic-related genes in liver were significantly decreased in the BCG injected mice. We also exposed human hepatocellular carcinoma HepG2 cells to high levels of palmitate, which enhanced endoplasmic reticulum stress-related gene expression and impaired insulin-stimulated Akt phosphorylation (Ser473). BCG treatment ameliorated both of these detrimental events. The present study therefore suggested that BCG administration suppressed development of nonalcoholic fatty liver disease, at least partly, by alleviating fatty acid-induced insulin resistance in the liver.
論文
Public Library of Science
2015-06-03
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/37591
http://hdl.handle.net/20.500.12000/37591
https://u-ryukyu.repo.nii.ac.jp/records/2008831
https://doi.org/10.1371/journal.pone.0128676
info:doi/10.1371/journal.pone.0128676
26039731
PLOS ONE
10
6
none
https://u-ryukyu.repo.nii.ac.jp/record/2008831/files/Vol10no6.pdf