2024-03-29T13:52:28Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02011142
2023-08-03T05:32:52Z
1642838163960:1642838338003
1642838403551:1642838407795
DRD4 VNTR polymorphism in Oceanic populations
Naka, Izumi
Ohashi, Jun
Kimura, Ryosuke
Furusawa, Takuro
Yamauchi, Taro
Nakazawa, Minato
Natsuhara, Kazumi
Ataka, Yuji
Nishida, Nao
Ishida, Takafumi
Inaoka, Tsukasa
Matsumura, Yasuhiro
Ohtsuka, Ryutaro
open access
© 2012 The Anthropological Society of Nippon
DRD4
Melanesian
Micronesian
Polynesian
VNTR
To study the origin of Polynesians and the gene flow from Polynesian ancestors to indigenous Melanesians, a 48-bp variable number of tandem repeats (VNTR) in exon 3 of the dopamine D4 receptor (DRD4) gene was investigated for six Austronesian (AN)-speaking populations—two in Tonga (Nuku’alofa and Ha’apai), three in Solomon Islands (Munda, Paradise, and Rawaki, of whom Rawaki was a Micronesian migrant group), and one in Papua New Guinea (Balopa), and one Non-Austronesian (NAN)-speaking population in Papua New Guinea (Gidra). In these Oceanic populations, six VNTR alleles with 2 (2R) to 11 (7R) repeats were observed. The most frequent DRD4 VNTR allele was the 4R allele, although the allele frequencies of 2R and 7R varied markedly among them, characterized by high frequencies of 7R and lack of 2R in NAN-speaking Melanesians (Gidra), and high frequencies of 2R and low or null frequencies of 7R in AN-speaking Polynesians (Nuku’alofa and Ha’apai) and Micronesians (Rawaki). The allele frequency distribution of DRD4 VNTR in Polynesians was similar to that in Aboriginal Taiwanese (Ami and Atayal), supporting the hypothesis that Polynesian ancestors were derived from Southeast Asians (probably Taiwanese). A principal component analysis for Southeast Asian and Oceanic populations based on the DRD4 VNTR allele frequencies revealed that AN-speaking Melanesian populations were genetically placed between two AN-speaking Polynesian and one NAN-speaking Melanesian populations. These results provide evidence of gene flow from Polynesian ancestors to indigenous Melanesians while Polynesian ancestors passed through Melanesia.
論文
The Anthropological Society of Nippon
一般社団法人日本人類学会
2012
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/46977
http://hdl.handle.net/20.500.12000/46977
https://u-ryukyu.repo.nii.ac.jp/records/2011142
https://doi.org/10.1537/ase.110901
https://doi.org/10.1537/ase.110901
1348-8570
0918-7960
Anthropological Science
120
2
151
155
https://u-ryukyu.repo.nii.ac.jp/record/2011142/files/120_110901.pdf