2024-03-29T11:23:05Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02011163
2023-08-03T05:43:25Z
1642838163960:1642838338003
1642838403551:1642838407795
The role of polymorphisms associated with early tooth eruption in dental and occlusal traits in East Asian populations
Yamaguchi, Tetsutaro
Kawaguchi, Akira
Kim, Yong-Il
Haga, Shugo
Katayama, Koshu
Ishida, Hajime
Park, Soo-Byung
Maki, Koutaro
Kimura, Ryosuke
open access
Creative Commons Attribution-NonCommercial 3.0
https://creativecommons.org/licenses/by-nc/3.0/
Genetics
Tooth size
Orthodontic index
Objective: A recent study suggested that rs6504340, a polymorphism within the homeobox B (HOXB) gene cluster, is associated with the susceptibility for malocclusions in Europeans. The resulting malocclusions require orthodontic treatment. The aim of this study was to investigate the association of rs6504340 and other dentition-implicated polymorphisms with dental and occlusal traits in Korean and Japanese populations. Methods: The study participants included 223 unrelated Koreans from the Busan area and 256 unrelated Japanese individuals from the Tokyo metropolitan area. DNA samples were extracted from saliva specimens. Genotyping for rs6504340 and four single nucleotide polymorphisms (SNPs) that have been shown to be associated with the timing of first tooth eruption and the number of teeth at 1 year of age (rs10506525, rs1956529, rs9674544, and rs8079702) was performed using TaqMan assays. The Index of Orthodontic Treatment Need (IOTN), overjet, overbite, arch length discrepancy, crown sizes, and length and width of the dental arches were measured. Spearman’s correlation coefficients were calculated to evaluate relationships between rs6504340 and these dental/occlusal traits. Results: We evaluated the aesthetic components and dental health components of the IOTN in the Korean and Japanese populations and found that neither rs6504340 nor the other four SNPs showed any association with dental and occlusal traits in these East Asian populations. Conclusions: These negative results suggest that further research is needed to identify the genetic determinants of malocclusions in order to reach a consensus.
論文
The Korean Association of Orthodontists
2014
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/47018
http://hdl.handle.net/20.500.12000/47018
https://u-ryukyu.repo.nii.ac.jp/records/2011163
https://doi.org/10.4041/kjod.2014.44.2.96
https://doi.org/10.4041/kjod.2014.44.2.96
2234-7518
2005-372X
The Korean Journal of Orthodontics
44
2
96
102
https://u-ryukyu.repo.nii.ac.jp/record/2011163/files/kjod-44-96.pdf