2024-03-28T17:19:39Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02011263
2023-08-03T05:27:13Z
1642838163960:1642838338003
1642838403551:1642838407795
Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Yamauchi, Momoko
Kinjo, Takeshi
Parrott, Gretchen
Miyagi, Kazuya
Haranaga, Shusaku
Nakayama, Yuko
Chibana, Kenji
Fujita, Kaori
Nakamoto, Atsushi
Higa, Futoshi
Owan, Isoko
Yonemoto, Koji
Fujita, Jiro
open access
Creative Commons Attribution 4.0
https://creativecommons.org/licenses/by/4.0/
Serum markers that differentiate between tuberculous and non-tuberculous pneumonia would be clinically useful. However, few serum markers have been investigated for their association with either disease. In this study, serum levels of interferon gamma (IFN-γ), matrix metalloproteinases 1 and 9 (MMP-1 and MMP-9, respectively), and periostin were compared between 40 pulmonary tuberculosis (PTB) and 28 non-tuberculous pneumonia (non-PTB) patients. Diagnostic performance was assessed by analysis of receiver-operating characteristic (ROC) curves and classification trees. Serum IFN-γ and MMP-1 levels were significantly higher and serum MMP-9 levels significantly lower in PTB than in non- PTB patients (p < 0.001, p = 0.002, p < 0.001, respectively). No significant difference was observed in serum periostin levels between groups. ROC curve analysis could not determine the appropriate cut-off value with high sensitivity and specificity; therefore, a classification tree method was applied. This method identified patients with limited infiltration into three groups with statistical significance (p = 0.01), and those with MMP-1 levels < 0.01 ng/ mL and periostin levels ≥ 118.8 ng/mL included only non-PTB patients (95% confidence interval 0.0–41.0). Patients with extensive infiltration were also divided into three groups with statistical significance (p < 0.001), and those with MMP-9 levels < 3.009 ng/mL included only PTB patients (95% confidence interval 76.8–100.0). In conclusion, the novel classification tree developed using MMP-1, MMP-9, and periostin data distinguished PTB from non- PTB patients. Further studies are needed to validate our cut-off values and the overall clinical usefulness of these markers.
論文
Public Library of Science
2020-07-09
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/47365
http://hdl.handle.net/20.500.12000/47365
https://u-ryukyu.repo.nii.ac.jp/records/2011263
https://doi.org/10.1371/journal.pone.0227636
https://doi.org/10.1371/journal.pone.0227636
1932-6203
PLoS ONE
15
1
https://u-ryukyu.repo.nii.ac.jp/record/2011263/files/journal.pone.0227636.pdf