2024-03-28T19:58:53Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02012418
2023-08-03T05:36:29Z
1642838163960:1642838338003
1642838403551:1642838407795
Kikuchi-Fujimoto disease in the regional lymph nodes with node metastasis in a patient with tongue cancer : A case report and literature review
Maruyama, Tessho
Nishihara, Kazuhide
Saio, Masanao
Nakasone, Toshiyuki
Nimura, Fumikazu
Matayoshi, Akira
Goto, Takahiro
Yoshimi, Naoki
Arasaki, Akira
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
https://creativecommons.org/licenses/by-nc-nd/4.0/
Kikuchi-Fujimoto disease
lymph node metastasis
necrosis
recurrence
pathology
clinical
tongue
cancer
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare self‑limiting disorder typically affecting the cervical lymph nodes (LNs), which is often misdiagnosed as other LN‑associated diseases. KFD frequently presents with necrotic lesions and recurrences, which are also features of metastatic LNs. Clinicians may thus suspect LN metastasis when they encounter ipsilateral cervical lymphadenopathy in a patient with head and neck cancer. The present study reports the case of a 48‑year‑old man with tongue cancer and KFD affecting the right edge of his tongue and ipsilateral cervical LNs. LN metastasis was initially suspected, but pathological examination of the dissected LNs revealed one necrotic metastatic lesion and two necrotic KFD lesions. Ipsilateral cervical lymphadenopathy recurred 6 years after the initial surgery, and it was not possible to differentiate clinically between a second primary tumor and recurrent KFD prior to treatment. To the best of our knowledge, this is the first reported case of simultaneous tongue cancer, regional LN metastasis and KFD. This highlights the requirement to consider KFD in the event of LNs with necrotic lesions but no cancerous cells. A combination of clinical and pathological approaches may aid in the diagnosis of KFD, in addition to ruling out LN metastasis in initial and recurrent lymphadenopathies. The present study indicate that a diagnosis of KFD should be considered in patients with head and neck cancer that exhibit necrotic LNs lacking cancerous cells. This is important, as misdiagnosis of KFD as LN metastasis may lead to unnecessary adjuvant therapy.
論文
Spandidos Publications
2017-07
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/45981
http://hdl.handle.net/20.500.12000/45981
https://u-ryukyu.repo.nii.ac.jp/records/2012418
https://doi.org/10.3892/ol.2017.6139
https://doi.org/10.3892/ol.2017.6139
1792-1074
1792-1082
Oncology Letters
14
1
257
263
https://u-ryukyu.repo.nii.ac.jp/record/2012418/files/ol_14_1_257_PDF.pdf