2024-03-29T04:39:16Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02012545
2023-08-03T05:36:12Z
1642838163960:1642838338003
1642838403551:1642838407795
Long-term Treatment of Teicoplanin for Methicillin-resistant Staphylococcus aureus Sternal Osteomyelitis with Renal Impairment : A Case of High Teicoplanin Trough Levels Maintained by Therapeutic Drug Monitoring
Shiohira, Hideo
Nakamatsu, Masashi
Kise, Yuya
Higa, Futoshi
Tateyama, Masao
Hokama, Nobuo
Kuniyoshi, Yukio
Ueda, Shinichiro
Nakamura, Katsunori
Fujita, Jiro
open access
© 2016 The Pharmaceutical Society of Japan
teicoplanin
therapeutic drug monitoring
renal impairment
methicillin-resistant Staphy lococcus aureus
bacteremia
Teicoplanin, a glycopeptide antibiotic for methicillin-resistant Staphylococcus aureus, is recommended for therapeutic drug monitoring during treatment. Maintaining a high trough range of teicoplanin is also recommended for severe infectious disease. However, the optimal dose and interval of treatment for severe renal impairment is unknown. We report a 79-year-old man who received long-term teicoplanin treatment for methicillin-resistant Staphylococcus aureus bacteremia due to postoperative sternal osteomyelitis with renal impairment. Plasma teicoplanin trough levels were maintained at a high range (20-30 μg/mL). Although the patient required long-term teicoplanin treatment, a further decline in renal function was not observed, and blood culture remained negative after the start of treatment. Teicoplanin treatment that is maintained at a high trough level by therapeutic drug monitoring might be beneficial for severe methicillin-resistant Staphylococcus aureus infection accompanied by renal impairment.
論文
The Pharmaceutical Society of Japan
日本薬学会
2016-09-01
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/46425
http://hdl.handle.net/20.500.12000/46425
https://u-ryukyu.repo.nii.ac.jp/records/2012545
https://doi.org/10.1248/yakushi.15-00296
https://doi.org/10.1248/yakushi.15-00296
1347-5231
0031-6903
YAKUGAKU ZASSHI
136
9
1313
1317
https://u-ryukyu.repo.nii.ac.jp/record/2012545/files/136_15-00296.pdf