2024-03-28T13:58:20Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02012566
2023-08-03T05:36:13Z
1642838163960:1642838338003
1642838403551:1642838407795
Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum
Takayama, Chitoshi
Inoue, Yoshiro
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0
https://creativecommons.org/licenses/by-nc-nd/4.0/
NKCC1
GABA
synaptophysin
vesicular GABA transporter
climbing fiber
Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl--concentration regulated by K+-Cl- co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.
論文
Elsevier
2007-02
eng
journal article
AM
http://hdl.handle.net/20.500.12000/46549
http://hdl.handle.net/20.500.12000/46549
https://u-ryukyu.repo.nii.ac.jp/records/2012566
https://doi.org/10.1016/j.neures.2006.10.016
https://doi.org/10.1016/j.neures.2006.10.016
0168-0102
Neuroscience Research
57
2
322
325
https://u-ryukyu.repo.nii.ac.jp/record/2012566/files/Figure2.tif
https://u-ryukyu.repo.nii.ac.jp/record/2012566/files/Figure1.tif
https://u-ryukyu.repo.nii.ac.jp/record/2012566/files/57.2.pdf