2024-03-29T01:52:18Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02012587
2022-10-31T07:05:36Z
1642838158423:1642838158860:1642838159351
1642838403551:1642838409905
Quantitative Emphysema Measurement On Ultra-High-Resolution CT Scans
Xu, Yanyan
徐, 妍妍
open access
© 2019 Xu et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License
http://creativecommons.org/licenses/by-nc/3.0/
chronic obstructive pulmonary disease
computed tomography
emphysema
ultra-high-resolution CT
quantitative measurement
Purpose: To evaluate the advantages of ultra-high-resolution computed tomography (U-HRCT) scans for the quantitative measurement of emphysematous lesions over conventional HRCTscans. Materials and methods: This study included 32 smokers under routine clinical care who underwent chest CT performed by a U-HRCT scanner. Chronic obstructive pulmonary disease (COPD) was diagnosed in 13 of the 32 participants. Scan data were reconstructed by 2 different protocols: i) U-HRCT mode with a 1024×1024 matrix and 0.25-mm slice thickness and ii) conventional HRCT mode with a 512×512 matrix and 0.5-mm slice thickness. On both types of scans, lesions of emphysema were quantitatively assessed as percentage of low attenuation volume (LAV%, <−950 Hounsfield units). LAV% values determined for scan data from the U-HRCT and conventional HRCT modes were compared by the Wilcoxon matched-pairs signed rank test. The association between LAV% and forced expiratory volume in 1 s per forced vital capacity (FEV_1/FVC) was assessed by the Spearman rank correlation test. Results: Mean values for LAV% determined for the U-HRCT and conventional HRCT modes were 8.9 ± 8.8% and 7.3 ± 8.4%, respectively (P<0.0001). The correlation coefficients for LAV% and FEV_1/FVC on the U-HRCT and conventional HRCT modes were 0.50 and 0.49, respectively (both P<0.01). Conclusion: Compared with conventional HRCT scans, U-HRCT scans reveal emphysematous lesions in greater detail, and provide slightly increased correlation with airflow limitation.
学位論文
University of the Ryukyus
2019-10-08
eng
doctoral thesis
VoR
http://hdl.handle.net/20.500.12000/46665
http://hdl.handle.net/20.500.12000/46665
https://u-ryukyu.repo.nii.ac.jp/records/2012587
http://doi.org/10.2147/COPD.S223605
http://doi.org/10.2147/COPD.S223605
1178-2005
International Journal of Chronic Obstructive Pulmonary Disease
14
2283
2290
乙第227号
博士(医学)
2020-01-29
18001
琉球大学
https://u-ryukyu.repo.nii.ac.jp/record/2012587/files/iron227text.pdf
https://u-ryukyu.repo.nii.ac.jp/record/2012587/files/iron227review.pdf
https://u-ryukyu.repo.nii.ac.jp/record/2012587/files/iron227abstract.pdf