2024-03-29T12:09:18Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02015610
2022-10-31T07:41:05Z
1642838163960:1642838198944:1642838199408:1642838222238
1642838403551:1642838412624
[原著]Carboplatin Selective Intra arterial Infusion Chemotherapy with Concurrent Radiotherapy on Cervical Lymph Node Metastasis in Squamous Cell Carcinoma in the Oral Region
Kuang, Hai
Sunakawa, Hajime
Arasaki, Akira
Arakaki, Keiichi
Nakasone, Toshiyuki
Ueda, Gosei
Gibo, Masaki
open access
琉球医学会
Ryukyu Medical Association
Selective intra-arterial infusion chemotherapy
Cervical lymph node metastasis
Carboplatin
Squamous cell carcinoma
Oral region
In this retrospective study, we evaluated the effect of carboplatin (CBDCA) selective intra-arterial infusion chemotherapy with concurrent radiotherapy (SIACR) on cervical lymph node metastasis in patients with squamous cell carcinoma in the oral region, and determined the factors related to this effect. Twenty seven patients were enrolled with biopsy-proven squamous cell carcinoma of the oral region. They received CBDCA SIACR for cervical lymph node metastasis and underwent neck dissection. For all patients, 38 metastatic lymph nodes were diagnosed using a number of criteria. The short-axis diameters of lymph nodes were measured on CT images before and after SIACR. All metastatic lymph nodes were histologically classified into complete, good, or poor responses according to their histological features. Level I metastatic lymph nodes were classified as proximal or distal according to the position of the tip of the microcatheter in the feeding artery. In 9 of 27 patients, computed tomography angiography (CTA) was performed to evaluate the vascularity and extent of the primary tumor and metastatic lymph nodes. The reduction percentage of lymph node short-axis diameters was 0%-58.3% with a mean of 26%. Complete response nodes ($36%\pm12%$) showed a significant reduction in short-axis diameters compared with good ($24%\pm15%$) and poor ($27%\pm11%$) response nodes (P<0.05). In the proximal group, 0, 5(63%) and 3 (37%) lymph nodes exhibited complete, good and poor responses. In the distal group, 4 (44%), 5 (56%) and 0 lymph nodes exhibited complete, good and poor responses. The difference between the proximal and distal groups' histological response was statistically significant ( P<0.05). No lymph nodes identified by CTA exhibited a poor response. A correlation between reduction in short-axis diameters of lymph nodes and histological responses was demonstrated in which reduction rates increased with histological response. Findings indicated that histological response was greater for patients in whom the tip of the microcatheter was placed distal to the branching site of the ascending palatine artery. The group with confirmed contrast medium transport to the lymph node metastasis by CT angiography showed a better therapeutic effect, highlighting the importance of confirmation of drug transport by CT angiography.
論文
琉球医学会
Ryukyu Medical Association
2005
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/0002015610
https://u-ryukyu.repo.nii.ac.jp/records/2015610
1346-888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
24
3・4
127
136
https://u-ryukyu.repo.nii.ac.jp/record/2015610/files/v24p127.pdf