2024-03-29T13:44:56Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02015920
2022-10-31T07:46:58Z
1642838163960:1642838198944:1642838199408:1642838201426
1642838403551:1642838412624
[原著]リドカイン代謝に及ぼすブピバカインの影響 : in vitro, in vivo での検討
Effects of Bupivacaine on in vitro and in vivo Lidocaine metabolism
磯, 淳典
平良, 豊
垣花, 脩
濱田, 哲
奥田, 佳朗
Iso, Atunori
Taira, Yutaka
Kakinohana, Osamu
Hamada, Satosi
Okuda, Yoshiaki
open access
琉球医学会
biotransformation
pharmacokinetics
enzyme inhibition
lidocain
bupivacaine
To evaluate the effects of bupivacaine on lidocaine metabolism mediated by chtochrome P-450, we analyzed enzyme kinetics in an in vitro study using rat liver microsomes and pharmacokinetics in an in vivo study using anesthetized dogs. In vitro study,bupivacaine showed mixed type inhibition of hdocaine metabolism with inhibition constants being 1.38mM. Since bupivacaine did not affect cytochrome C reductase activity,this inhibition of lidocaine metabolism may have been caused by the action on cytochrome P-450. In vivo study, there was no difference between pharmacokinetic parameter after lidocaine alone injection and lidocaine mixed with bupivacaine injection.
論文
琉球医学会
Ryukyu Medical Association
1992
jpn
journal article
VoR
http://hdl.handle.net/20.500.12000/0002015920
https://u-ryukyu.repo.nii.ac.jp/records/2015920
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
12
4
375
382
https://u-ryukyu.repo.nii.ac.jp/record/2015920/files/v12p375.pdf