2024-03-28T10:37:51Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02016002
2022-10-31T07:48:27Z
1642838163960:1642838198944:1642838199408:1642838208619
1642838403551:1642838412624
[原著]Predicting factors and efficacy of interferon alpha therapy in patients with liver cirrhosis associated with HCV infection
Nakasone, Hiroki
Sgkuawa, Hiroshi
Nakayoshi, Tmofumi
Kawakami, Yuko
Kinjo, Fukunori
Saito, Atushi
Yamashiro, Akiko
Nakayoshi, Tmokuni
Ikema, Minoru
Hirayama, Yoshikatsu
open access
琉球医学会
interferon alpha
liver cirrhosis
hepatitis type C
The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients with liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with IFN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.
論文
琉球医学会
Ryukyu Medical Association
1996
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/0002016002
https://u-ryukyu.repo.nii.ac.jp/records/2016002
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
16
3
117
121
https://u-ryukyu.repo.nii.ac.jp/record/2016002/files/v16p117.pdf