2024-03-28T11:35:38Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02016127
2022-10-31T07:50:57Z
1642838163960:1642838198944:1642838199408:1642838216682
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[総説]The roles of alveolar type II epithelial cells in acute lung injury and repair
Sugahara, Kazuhiro
Nakamura, Seiya
Teruya, Kohji
open access
琉球医学会
acute lung injury
surfactant protein
wound healing
alveolar epithelial cells
in situ hybridization
Regeneration of alveolar epithelial cells is one of the important repair processes in many types of lung injury. Alveolar type II cells have two major functions, one is to serve as the site of surfactant production and the second is to serve as a progenitor cell for alveolar type I cells, particularly during re-epithelialization after lung injury. We have examined effect of several soluble factors on cultured alveolar type II cells in vitro, and also examined the sequential analysis of histopathology and gene expressions of surfactant proteins in alveolar epithelial cells of rats with lipopolysaccharide (LPS)-, bleomycin-, and/or KGF-treated lungs. We have found that KGF is a specific stimulator for alveolar epithelial cells, and KGF instillation prevents bleomycin induced lung injury. KGF may play an important role in maintaining alveolar epithelium and repairing the damaged epithelium after injury. This review will give an overview of the roles of alveolar type II cells in the repairing processes of acute lung injury and fibrosis.
論文
琉球医学会
Ryukyu Medical Association
2001
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/0002016127
https://u-ryukyu.repo.nii.ac.jp/records/2016127
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
20
4
161
166
https://u-ryukyu.repo.nii.ac.jp/record/2016127/files/v20p161.pdf