2024-03-29T15:04:39Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02016208
2022-02-22T04:42:53Z
1642838163960:1642838198944:1642838199408:1642838216134
1642838403551:1642838412624
[総説]I型アレルギーにおけるIgEとその受容体Fc$ \varepsilon $RIの相互反応
Interaction between IgE and its receptor (Fc$ \varepsilon $RI) in type-I allergy
花城, 和彦
渡慶次, 賀博
島田, 誠二
砂川, 昌範
中村, 真理子
小杉, 忠誠
Hanashiro, Kazuhiko
Tokeshi, Yoshihiro
Shimada, Seiji
Sunagawa, Masanori
Nakamura, Mariko
Kosugi, Tadayoshi
open access
琉球医学会
Type-I allergy
IgE-mediated inflammation
Fc$ \varepsilon $RI
The type-I allergy is mediated by the interaction between IgE and its high affinity receptor (Fc$ \varepsilon $RI) followed by cross-linking with specific allergen. The binding site for the IgE was identified on the Fc$ \varepsilon $RI $ \alpha $ subunit, and the soluble $ \alpha $ subunit of Fc$ \varepsilon $RI was effective in controlling the lgE-mediated inflammation. Recent studies using IgE knock out mice revealed that IgG could also induce anaphylaxis. However, in the Fc$ \varepsilon $RI $ \alpha $ subunit knock out mice, IgE and IgG could not induce anaphylaxis. These results demonstrated that Fc$ \varepsilon $RI expression is essential for the development of the IgE-mediated inflammation. Further investigation on the interaction between IgE and Fc$ \varepsilon $Rl $ \alpha $ subunit on the membrane of target cells and on signal transduction in the cytoplasma and nucleus should offer novel concepts in developing strategies for the treatment of IgE-mediated inflammation.
論文
琉球医学会
Ryukyu Medical Association
jpn
journal article
VoR
http://hdl.handle.net/20.500.12000/0002016208
https://u-ryukyu.repo.nii.ac.jp/records/2016208
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
20
3
117
127
https://u-ryukyu.repo.nii.ac.jp/record/2016208/files/v20p117.pdf