2024-03-29T07:48:27Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02019653
2023-08-03T05:38:03Z
1642838163960:1642838338003
1642838403551:1642838407795
Survivin: A novel marker and potential therapeutic target for human angiosarcoma
Tsuneki, Masayuki
Kinjo, Takao
Mori, Taisuke
Yoshida, Akihiko
Kuyama, Kayo
Ohira, Aoi
Miyagi, Takuya
Takahashi, Kenzo
Kawai, Akira
Chuman, Hirokazu
Yamazaki, Naoya
Masuzawa, Mikio
Arakawa, Hirofumi
open access
© 2017 The Authors
This is an open access article under the terms of the Creative Commons Attrib ution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Human angiosarcoma is a rare malignant vascular tumor associated with extremely poor clinical outcome and generally arising in skin of the head and neck region. However, little is known about the molecular pathogeneses and useful immunohistochemical markers of angiosarcoma. To investigate the mechanisms of angiosarcoma progression, we collected 85 cases of human angiosarcoma specimens with clinical records and analyzed ISO-HAS-B patient-derived angiosarcoma cells. As control subjects, 54 cases of hemangioma and 34 of pyogenic granuloma were collected. Remarkably, consistent with our recent observations regarding the involvement of survivin expression following Hippo pathway inactivation in the neoplastic proliferation of murine hemangioendothelioma cells and human infantile hemangioma, nuclear survivin expression was observed in all cases of angiosarcoma but not in hemangiomas and pyogenic granulomas, and the Hippo pathway was inactivated in 90.3% of yes-associated protein (YAP)-positive angiosarcoma cases. However, survivin expression modes and YAP localization (Hippo pathway activation modes) were not correlated with survival. In addition, we confirmed that survivin small interference RNA (siRNA) transfection and YM155, an anti-survivin drug, elicited decreased nuclear survivin expression and cell proliferation in ISO-HAS-B cells which expressed survivin consistently. Conclusively, these findings support the importance of survivin as a good marker and critical regulator of cellular proliferation for human angiosarcoma and YM155 as a potential therapeutic agent.
Wiley Open Access
2017-11
eng
journal article
VoR
http://hdl.handle.net/20.500.12000/0002019653
https://u-ryukyu.repo.nii.ac.jp/records/2019653
https://doi.org/10.1111/cas.13379
1347-9032
1349-7006
Cancer Science
108
11
2295
2305
https://u-ryukyu.repo.nii.ac.jp/record/2019653/files/CAS-108-2295.pdf
3 MB