2024-03-29T05:34:53Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02007279
2022-10-31T03:18:02Z
1642838158423:1642838158860:1642838159351
1642838403551:1642838409905
Effects of Insulin-induced Hypoglycemia on Cerebrovascular Permeability in Diabetic Rats
Tanaka, Hideaki
田中, 秀明
cerebrovascular permeability
insulin-induced hypoglycemia
streptozotocin-diabetic rats
Evans blue
alburnin tracer
報告番号(甲第19号)
We studied the effect of insulin-induced hypoglycemia in both normal and streptozotocin-diabetic rats with two different durations of diabetes : 3 months and 6 months. The study was carried out in order to investigate : (a) whether diabetes alters cerebrovascular permeability, (b) whether the alteration of cerebrovascular permeability is changed by insulin-induced hypoglycemia. and (c) the relationship between the duration of the diabetic state and blood-brain barrier permeability. Evans blue fluorescence was used as an albumin tracer. In the basal condition, diabetic rats showed a significant increase in cerebrovascular permeability compared with normal rats. Insulin-induced hypoglycemia significantly enhanced cerebrovascular permeability in both normal rats and diabetic rats. the 6-month diabetic rats demonstrated a significant increase in cerebrovascular permeability ompared with the 3-month diabetic rats. In summry, insulin-induced hypoglycemia was thus demonstrated to be associated with a significant increase of cerebrovascular permeability in diabetic rats in relation to the duration of their diabetic state. Although the clinical sigificance of the findings still remains unknown, the results suggest the possibility that a similar phenomenon might also occur in the brain of long-term diabetic patients with severe and prolonged hypoglycemia.
学位論文
博士(医学)
http://purl.org/coar/resource_type/c_db06
琉球大学
Tanaka Hideaki
1991-12
1991-12-25
VoR
http://hdl.handle.net/20.500.12000/25396
none
eng
琉球医学会誌.第12巻3号(1992年8月)
open access