2024-03-28T20:02:00Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02011134
2023-08-03T05:36:00Z
1642838163960:1642838338003
1642838403551:1642838407795
An Okhotsk adult female human skeleton (11th/12th century AD) with possible SAPHO syndrome from Hamanaka 2 site, Rebun Island, northern Japan
Okamoto, Yuka
Ishida, Hajime
Kimura, Ryosuke
Sato, Takehiro
Tsuchiya, Nanae
Murayama, Sadayuki
Fukase, Hitoshi
Nagaoka, Tomohito
Adachi, Noboru
Yoneda, Minoru
Andrzej, Weber
Kato, Hirofumi
SAPHO syndrome
Japanese archipelago
Okhotsk culture
human skeleton
hyperostosis
We present the oldest human skeletal case yet identified with possible SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a chronic disease involving the skin, bone, and joints. A human skeleton with a severe pathological condition was recovered from a shell mound of the prehistoric Okhotsk culture at the Hamanaka 2 site, Rebun Island, Hokkaido, Japan in 2013. Morphological and Amelogenin gene analyses determined the sex as female, and the age at time of death was estimated to be in the forties using analysis of the auricular surface of the ilium. The stable isotope ratios of this individual (NAT002) and other Hamanaka 2 samples indicated a heavy dependence on marine mammals and fish for dietary protein intake. Radiocarbon age on collagen from the bone of NAT002 was 1689 ± 20 BP, or 1060–1155 (68.2%) calAD. Macroscopic and computed tomography (CT) findings indicated diffuse hyperostosis in the axial and appendicular skeleton, including the mandible, vertebrae, clavicles, sternum, scapulae, humeri, radii, ulnae, and ilium, caused by osteitis and synovitis. The bilateral clavicles were most affected, in which CT imaging revealed irregular cortical thickening, termed ‘grotesque periostitis.’ The case was diagnosed as most likely having SAPHO syndrome, although dermatological findings could not be detected. Although SAPHO syndrome is a fairly new concept in autoimmune diseases, this case suggests the syndrome originated much earlier in human history.
論文
http://purl.org/coar/resource_type/c_6501
The Anthropological Society of Nippon
一般社団法人日本人類学会
2016
VoR
http://hdl.handle.net/20.500.12000/46970
1348-8570
0918-7960
Anthropological Science
2
124
115
107
eng
https://doi.org/10.1537/ase.160608
https://doi.org/10.1537/ase.160608
open access
© 2016 The Anthropological Society of Nippon