2024-03-28T17:21:57Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02012371
2023-08-03T05:31:21Z
1642838163960:1642838338003
1642838403551:1642838407795
Association of a sex-related difference of Strongyloides stercoralis-specific IgG4 antibody titer with the efficacy of treatment of strongyloidiasis
Satoh, Masao
Toma, Hiromu
Kiyuna, Susumu
Shiroma, Yoshiyuki
Kokaze, Akatsuki
Sato, Yoshiya
It is difficult to completely eradicate strongyloidiasis, a human intestinal nematode infection with Strongyloides stercoralis with drugs, especially in males. To find host factors involved in the response to treatment, patients infected with S. stercoralis were examined for S. stercoralis-specific antibody titers and the effect of treatment with albendazole on these titers were determined. The cure rate was slightly but not significantly lower in males than in females (P = 0.108). However, a significantly higher titer of S. stercoralis-specific IgG4 antibody was observed in males than in females (P = 0.0097), and the S. stercoralis-specific IgG4 antibody titer was significantly higher in the male non-cured group than in the cured group (P = 0.035). These results suggest that elevation of the S. stercoralis-specific IgG4 antibody titer is associated with resistance to treatment of S. stercoralis infection, especially in males.
論文
http://purl.org/coar/resource_type/c_6501
The American Society of Tropical Medicine and Hygiene
2004-07
VoR
http://hdl.handle.net/20.500.12000/45868
0002-9637
1476-1645
The American Journal of Tropical Medicine and Hygiene
1
71
111
107
eng
https://doi.org/10.4269/ajtmh.2004.71.107
https://doi.org/10.4269/ajtmh.2004.71.107
open access
The American Society of Tropical Medicine and Hygiene