2024-03-29T06:37:07Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02012388
2023-08-03T05:31:19Z
1642838163960:1642838338003
1642838403551:1642838407795
A Unique Subset of γδ T Cells Expands and Produces IL-10 in Patients with Naturally Acquired Immunity against Falciparum Malaria
Taniguchi, Tomoyo
Mannoor, Kaiissar Md
Nonaka, Daisuke
Toma, Hiromu
Li, Changchun
Narita, Miwako
Vanisaveth, Viengxay
Kano, Shigeyuki
Takahashi, Masuhiro
Watanabe, Hisami
γδ T cells
naturally acquired immunity
Plasmodium falciparum
falciparum malaria
IL-10
Although expansions in gamma delta T cell populations are known to occur in the peripheral blood of patients infected with Plasmodium falciparum, the role of these cells in people with naturally acquired immunity against P. falciparum who live in malaria-endemic areas is poorly understood. We used a cross-sectional survey to investigate the role of peripheral blood gamma delta T cells in people living in Lao People's Democratic Republic, a malaria-endemic area. We found that the proportion of non-V gamma 9 gamma delta T cells was higher in non-hospitalized uncomplicated falciparum malaria patients (UMPs) from this region. Notably, we found that the non-V gamma 9 gamma delta T cells in the peripheral blood of UMPs and negative controls from this region had the potential to expand and produce IL-10 and interferon-gamma when cultured in the presence of IL-2 and/or crude P. falciparum antigens for 10 days. Furthermore, these cells were associated with plasma interleukin 10 (IL-10), which was elevated in UMPs. This is the first report demonstrating that, in UMPs living in a malaria-endemic area, a gamma delta T cell subset, the non-V gamma 9 gamma delta T cells, expands and produces IL-10. These results contribute to understanding of the mechanisms of naturally acquired immunity against P. falciparum.
論文
http://purl.org/coar/resource_type/c_6501
Frontiers Media
2017-07-19
VoR
http://hdl.handle.net/20.500.12000/45905
1664-302X
Frontiers in Microbiology
8
eng
https://doi.org/10.3389/fmicb.2017.01288
https://doi.org/10.3389/fmicb.2017.01288
open access
Creative Commons Attribution 4.0
https://creativecommons.org/licenses/by/4.0/