2024-03-28T22:32:15Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02015585
2022-10-31T07:40:38Z
1642838163960:1642838198944:1642838199408:1642838225283
1642838403551:1642838412624
[原著]心拍数と心血管疾患との関連 : 外来患者における断面解析
The Association Between Heart Rate and Cardiovascular Disease:A Cross-sectional Analysis of Ambulatory Patients
井上, 卓
新里, 譲
Inoue, Taku
Shinzato,Yuzuru
Heart rate
Cardiovascular disease
Metabolic syndrome
Chronic kidney disease
Background: Elevated heart rate is closely associated with cardiovascular morbidity, mortality and all-cause mortality. Elevated heart rate is also associated with cardiovascular risk factors. The aim of the present study was to evaluate whether elevated heart rate is associated with cardiovascular morbidity independent of cardiovascular risk factors. Methods & Results: We examined the association between heart rate and cardiovascular morbidity of ambulatory patients. Of 102 patients, 3 were excluded because of low ejection fraction. Among the remaining 99 subjects (54 men, 45 women, $66 pm 12$ years of age), 34 (20 men, 14 women, $ 71\pm 8$ years of age) had a history of cardiovascular disease. The subjects with cardiovascular disease were significantly older, and had lower systolic blood pressure and lower total cholesterol levels than those without cardiovascular disease. Multivanable logistic regression analysis adjusted for age, sex, and antihypertensive agents revealed that a 20 beats/min heart rate increase was associated with an approximately 4-fold increase in the risk for cardiovascular disease (OR 3.597, 95% CI 1.456 - 8.888, p=0.0055). Metabolic syndrome (OR 1.276, 95% CI 0.434 - 3.752, p=NS) and chronic kidney disease (OR 0.736, 95% CI 0.238 - 2.279, p=NS) were not associated with cardiovascular disease. After excluding the patients prescribed such heart rate-lowering drugs as $ \beta $ -antagonist or diltiazem, heart rate increase was still the only factor associated with the risk for cardiovascular disease ( OR3.692, 95% CI 1.123 - 12.137, p=0.0351). Conclusions: Elevated heart rate is closely associated with cardiovascular morbidity independent of other cardiovascular risk factors such as metabolic syndrome or chronic kidney disease.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
Ryukyu Medical Association
2008
VoR
1346-888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
3・4
27
129
123
jpn
open access
琉球医学会