2024-03-29T15:49:00Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02015626
2022-10-31T07:41:24Z
1642838163960:1642838198944:1642838199408:1642838225771
1642838403551:1642838412624
[原著]ミャンマー人における口唇口蓋裂発症とMTHFR遺伝子C677T多型の関連に対する検討
Association of MTHFR Gene Polymorphisms on Nonsyndromic Isolated Cleft Lip and with or without cleft palate in a Myanmar population.
後藤, 尊広
新垣, 敬一
國仲, 梨香
石川, 拓
仲間, 錠嗣
夏目, 長門
大関, 悟
砂川, 元
Goto, Takahiro
Arakaki, Keiichi
Kuninaka, Rika
Ishikawa, Taku
Nakama, Joji
Natsume, Nagato
Ozeki, Satoru
Sunakawa, Hajime
isolated non-syndromic cleft lip with or without palate
Myanmar
folate
5
10-methylenetetrahydrolate reductase
Objective: The aim of this study was to evaluate the association between folate metabolizing enzyme gene polymorphism, 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T and the development of isolated non-syndromic cleft lip with or without cleft palate (NSCL/P) in a Myanmar population. Patients/- Participants: We examined 156 Myanmar isolated NSCL/P patients, 96 their mothers and 64 their fathers compared to 109 controls. Results: The genotype and allele frequencies of MTHFR C677T in Myanmar isolated NSCL/P did not show statistically differences between the patient and the control group (p=0.813, 0.535) as well as the father (p=0.513, 0.267), the mother (p=0.501, 0.420) and the control group (Genotype frequency, Allele frequency). Conclusion: Our results did not suggest that MTHFR C677T polymorphism does not make a important role in the development of isolated NSCL/P in a Myanmar population.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
Ryukyu Medical Association
2009
VoR
1346-888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
1・2
28
29
25
jpn
open access
琉球医学会