2024-03-28T11:43:27Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02015821
2022-10-31T07:45:08Z
1642838163960:1642838198944:1642838199408:1642838199879
1642838403551:1642838412624
[原著]The Effects of Ethanol Oral Administration and Toluene Inhalation Exposure on Plasma Free Large Neutral Amino Acids in Wistar Rats
Dominicus, Dalmas A. R.
ethanol
toluene
neutral amino acids
branched chain amino acids
aromatic amino acids
behavioural changes
To investigate the effects of ethanol or tuluene on the large neutral amino acids (LNAA) and plasma ratios tryptophan/LNAA and tyrosine/LNAA, known under physiological conditions to predict the brain concentrations of tryptophan and tyrosine respectively, a study was carried out involving Male Wistar rats divided into alcohol (ethanol) 20 rats, and toluene inhalation 20 rats, for a period of two months. Using t test ethanol oral administration caused consistent and significant increase in plasma branched chain amino acids (BCAA). Ethanol also caused a significant decrease in plasma ratio of tryptophan/LNAA. Toluene showed no effect on the BCAA as well as the plasma ratio of tryptophan/LNAA, but caused a significant increase in plasma ratio of tyrosine/LNAA. Tryptophan is the precusor of cerebral indolylamine 5-hydroxytryptamine (5-HT) , which is believed to be involved in neurotransmission and regulation of mood and possibly also certain other behaviours. Therefore the plasma amino acid characteristics observed in this study may contribute to sustaining or accentuating mood and behavioural changes seen in alcoholics. More research is needed in this area to help in varifying these findings especially in human subjects who are alcoholics or those exposed to toluene.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
Ryukyu Medical Association
1991
VoR
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
1
12
33
22
eng
open access
琉球医学会