2024-03-28T19:11:36Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02015970
2022-10-31T07:47:53Z
1642838163960:1642838198944:1642838199408:1642838209048
1642838403551:1642838412624
[原著]Effects of dietary supplementation of nucleoside-nucleotide mixture and its components upon graft vs host and host vs graft responses in mice
Kakinohana, Shige
Adjei, AndrewA
Ameho, ClementK
Yamauchi, Keiko
Wang, Ming-Fu
Chung, Hei-Mei
Yamamoto, Shigeru
nucleosides
nucleotides
graft vs host
popliteal lymph node
mice
We studied the effects of individual components of a nucleoside-nucleotide mixture on the lymphocyte responses to allonantigens in popliteal lymph node (PLN) of mice. Mice were fed for 4 weeks a nucleotide-free 20% casein diet (control), or this diet supplemented with 3 mol/kg of one of the followings; inosine, guanosine monophosphate (GMP 2Na), uridine, cytidine, thymidine, or a mixture of these. In the graft vs host reaction, there was no difference in the PLN weights and the expression of CD4 and CD8 surface markers among the groups. In the host vs graft reaction there was a significant increase in the PLN weights between the mice fed the supplemented diets and the nucleotide-free dietary group (control). However, there was no difference between the mixture and the individual component diet groups. Except for GMP 2Na and cytidine supplemented groups, there was a difference in the expression of CD4 surface marker in the supplemented groups as compared to the control dietary group; the CD4^+ cells significantly increased in the supplemented groups, although there was no difference between the mixture and individual componenets supplemented groups. We conclude that mice fed the nucleoside-nucleotide mixture and the individual component of the mixture had enhancing effects in the host vs graft responses studied and that the effects in mice fed the mixture were not different from those in mice fed the individual component.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
Ryukyu Medical Association
1996
VoR
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
4
16
170
165
eng
open access
琉球医学会