2024-03-29T14:16:45Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02015971
2022-10-31T07:47:54Z
1642838163960:1642838198944:1642838199408:1642838206792
1642838403551:1642838412624
[総説]Physiological significance of protease in airway secretion and the control of inflammation in airway tract by protease inhibitor
Tamaki, Noboru
Kosugi, Tadayoshi
Hanashiro, Kazuhiko
Nakamura, Mariko
protease
antiprotease
plasminogen activator
tracheobronchial secretion
We review the action of protease in airway inflammation from the standpoint of the protease-antiprotease system. The tracheobronchial secretion without inflammation has an abundant protease, plasminogen activator (PA) , which plays an important role in the continuous opening of the tracheobronchial lumina. Immediately after inflammation occurs in the airway tract, the protease activity is increased in the airway secretion, as compared to the protease activity in other organs. On the other hand, increased protease secretion, plays a strong role in the enlargement and exacerbation of the inflammation. In physiological inflammation, the increased protease activity is mediated and inhibited by protease inhibitor which is concomitantly elevated at the inflammatory locus. In inflammation of the airway tract, therefore, the application and supply of protease inhibitor to the airway tract, should cause the inflammation to subside. We consider that the role of protease inhibitor in limiting the inflammation of the airway tract is of clinical importance.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
Ryukyu Medical Association
1995
VoR
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
3
15
126
121
eng
open access
琉球医学会