2024-03-28T22:35:40Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02016039
2022-10-31T07:49:09Z
1642838163960:1642838198944:1642838199408:1642838211541
1642838403551:1642838412624
[総説]排卵への蛋白分解酵素の役割 : (2)コラーゲン分解系の役割
The role of proteolytic enzymes in ovulation : The role of collagenolytic system
小杉, 忠誠
砂川, 昌範
花城, 和彦
金城, 紀代彦
中村, 真理子
Kosugi, Tadayoshi
Sunagawa, Masanori
Hanashiro, Kazuhiko
Kinjoh, Kiyohiko
Nakamura, Mariko
interstitial collagenase
type IV collagenase
collagenase inhibitor
tissue inhibitor of metalloproteinase 1
procollagenase
Extracellular matrix of the ovary during ovulation is degraded and remodelled. After ovulation, angiogenesis and repair occur in the ovary. The dynamic change of extracellular matrix during ovulation is based on the role of proteolytic enzymes. Besides the fibnnolytic enzymes, the enzymes of collagenolytic system play important role in ovulation. In this article, we report that interstitial collagenase, type IV collagenase, collagenase inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP-1) which belong to collagenolytic system play important role in the rupture of follicle, the migration of oocyte and the expulsion of oocyte from the ovary. During gonadotropin-induced ovulation, at 3 hr to 6 hr after hCG administration the interstitial collagenase mRNA increased, but at 9 hr after hCG administration TIMP-I mRNA and collagenase type IV mRNA increased in the granulosa cell, thecal compartment and stroma compartment. Both the interstitial collagenase and type IV collagenase were secreted in the latent form (procollagenase). This latent form, procollagenase was activated by fibrinolytic enzyme, plasmin and converted to active collagenase. It was clarified that the cross talk of fibrinolytic enzymes and collagenolytic enzyme has been observed in the process of ovulation.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
Ryukyu Medical Association
1998
VoR
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
1-2
18
14
11
jpn
open access
琉球医学会