2024-03-28T22:24:32Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02016132
2022-10-31T07:51:02Z
1642838163960:1642838198944:1642838199408:1642838218204
1642838403551:1642838412624
[原著]Age related changes in event-related potentials and psychological testing in healthy elderly subjects
Yu, Jin
Hiramatsu, Kenichi
Shimazaki, Yoriyuki
Takeda, Yuko
Event-related potentials
P300
Aging
MMS
Elderly
P300 latency in event-related potentials (ERPs) have been assumed to increase with age, and to be roughly correlated with loss of cognitive functions. However, is P300 latency prolonged in all elderly subjects? To address this question, we selected 63 subjects from 60 to 91 years of age. Subjects were active, living at home, free from psychiatric or significant physical disorders, having high Mini-Mental State (MMS) score and low Geriatric Depression Scale (GDS) score, and showed no major signs of cerebral infarction on MRI (1.5T). ERPs were recorded with subjects engaged in auditory oddball tasks. We found no significant correlation between age and P300 component. Sex difference concerning P300 component with aging was also not detected. P300 latency prolongation and decreased visual retention (Benton test) were associated with lower MMS score, and visual retention was correlated with age. We conclude that P300 latency does not increase linearly with age in elderly subjects and that prolongation of latency is affected by subclinical organic changes in the brain than by aging itself.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
Ryukyu Medical Association
2002
VoR
1346888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
3-4
21
132
125
eng
open access
琉球医学会