2024-03-28T14:40:20Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02016240
2022-02-22T04:44:04Z
1642838163960:1642838198944:1642838199408:1642838227236
1642838403551:1642838412624
[原著]HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production
Takemoto, Hiroyuki
Kina, Shinichiro
Arakaki, Keiichi
Matayoshi, Akira
Liang, Feixin
Phonaphonh, Thongsavanh
Kuang, Hai
Sunakawa, Hajime
嵩元, 裕之
喜名, 振一郎
新垣, 敬一
又吉, 亮
砂川, 元
HPV
H_2O_2
IL-8
Angiogenesis induced by inflammation occurs in infected sites and is crucial for the initiation of cancer progression. In cervical cancer, IL-8 (Interleukin-8) production is linked to cancer progression. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal, including ROS. Here, we show that a ROS (H_2O_2) activates p38 MAPK to increase the expression of IL-8 in HeLa cells (HPV18-positive cells). We found that knockdown of HPV (Human Papillomavirus) E6 inhibited H_2O_2- and MG132-induced IL-8 production in HeLa cells. These findings elucidate an interesting signaling pathway by which inflammation can induce angiogenesis to cause cervical cancer progression.
論文
http://purl.org/coar/resource_type/c_6501
琉球医学会
VoR
1346-888X
0289-1530
AN10369445
琉球医学会誌 = Ryukyu Medical Journal
3・4
29
30
23
eng
open access
琉球医学会