2024-03-28T11:03:43Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02016296
2022-02-22T04:45:50Z
1642838163960:1642838198944:1642838242961:1642838243524
1642838403551:1642838412624
[原著]特異動的作用(SDA)の発現機構に関する研究(Ⅱ) : 栄養素による肝組織の発熱機構とSDAの起源について
Studies on the Origin and Mechanism of Specific Dynamic Action (II) : the mechanism of thermogenesis in liver slices and the origin of SDA
安里, 龍
安良城, 旬子
新城, 澄枝
桜井, 隆
Asato, Liew
Arashiro, Junko
Shinjo, Sumie
Sakurai, Takashi
The amounts of heat generated by the liver slices incubated with glucose, amino acids, and glucose-amino acid mixtures were measured by using a micro-calorimeter. The order of magnitude in thermogenesis of the tissue slices with the various kinds of substrate composition, was as follows : G + E > G + E + NE -_~ E + NE > E > NE > G + NE > G where G stands for glucose, E for essential amino acid group and NE for non-essential amino acid group, respectively. Forty seven mcal, of heat per 30 minutes which was generated by liver slices incubated with essential amino acids-glycine mixtures was suppressed by 8 and 43 per cent in the presence of 2mM and 4mM of puromycin, respectively. The results mentiond above indicate that the relatively higher heat generation in the presence of glucose plus essential amino acid group would involve the contribution of the process of biosynthesis, particularly of the protein synthesis. In this case, glucose might have a role on supplying energy on the anabolic process. The amount of heat generated by the liver slices in the reconstructed system of urea synthesis was unexpectedly smaller than those in any other systems. This result apparently contradicts H. A. Kreps' hypothesis that urea synthesis is mainly responsible for the origin of SDA.
論文
http://purl.org/coar/resource_type/c_6501
琉球大学保健学部
College of Health Sciences, University of the Ryukyus
VoR
0285-9270
AN00250763
琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine
1
1
22
16
jpn
open access
琉球医学会