2024-03-29T02:26:12Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02018026
2022-06-09T03:03:19Z
1642838158423:1642838158860:1642838159351
1642838403551:1642838409905
Analysis of human hippocampal volumetry in relation to pattern separation ability in healthy young subjects
健常若年者におけるパターン分離能力に関連したヒト海馬体積測定による分析
宇杉, 竜一
Usugi, Ryoichi
dentate gyrus
hippocampal subfields
hippocampal-amygdaloid transition area HATA
pattern separation
volumetric MR
Introduction: Hippocampal dentate gyrus related to pattern separation has attracted attention as an area for neurogenesis. However, the associations between the pattern separation and the volumes of hippocampal subfields in humans remain unknown.
Methods: 58 young adults were examined the memory task (pattern separation, pattern completion) and the hippocampal volumes. Subjects were asked to determine whether the visual image is a new stimulus, or a similar but different stimulus (pattern separation), or the same stimulus (pattern completion), compared to preceding stimuli, and response time and correct response were measured. The volumes of the whole brain, hippocampus 6 subfields and perihippocampus 5 subfields, were measured using FreeSurfer 6.0.
Results: Negative associations between the pattern separation task and the volumes of whole brain areas were found in bilateral cerebellar cortex, fourth ventricle, left hippocampus, left thalamus, left ventral diencephalon, and brainstem. Simple linear regression analysis revealed a significant association with the left hippocampalamygdaloid transition area only, while no significant associations were found in any of the subfield volumes when adjusted with covariates.
Conclusions: The principle “bigger is better”―an idea that the larger the volume the better the function―could not be applied to the relation between the pattern separation ability and the dentate gyrus.
博士(医学)
http://purl.org/coar/resource_type/c_db06
琉球大学
琉球大学
University of the Ryukyus
2021-09-30
VoR
2162-3279
2157-9032
Brain and Behavior
12
10
甲第533号
eng
https://doi.org/10.1002/brb3.1878
open access
© 2020 The Authors
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.