2024-03-28T17:57:09Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02018034
2022-06-30T02:10:14Z
1642838158423:1642838158860:1642838159351
1642838403551:1642838409905
Microbiome analysis in women with endometriosis: does a microbiome exist in peritoneal fluid and ovarian cystic fluid?
子宮内膜症症例におけるマイクロバイオーム解析; 腹水と卵巣嚢腫内容液にマイクロバイオームは存在するのか?
大石, 杉子
Oishi, Sugiko
16S rRNA
endometriosis
microbiome
ovarian cystic fluid
peritoneal fluid
Purpose: To investigate the relationship between the microbiome of the female genital tract and endometriosis.
Methods: This prospective cohort study included 36 women who underwent laparoscopic surgery for ovarian tumor from July 2019 to April 2020. Of them, 18 had endometriosis, and 18 did not have endometriosis. Vaginal secretions, endometrial fluid, peritoneal fluid, and ovarian cystic fluid were collected during surgery. Next-generation sequencing of bacterial 16S rRNA was performed to characterize the microbiome.
Results: Specific microbiomes were not detected in either peritoneal fluid or ovarian cystic fluid regardless of the presence or absence of endometriosis and the type of cyst. When the cutoff value of infectious bacterial abundance in the vagina was set as 64.3%, there were many cases more than a cutoff value in the endometriosis group significantly (p = 0.01). When the cutoff value of infectious bacterial abundance in the endometrium was set as 18.6%, there were many cases more than a cutoff level in the endometriosis cases significantly (p = 0.02).
Conclusion: Peritoneal fluid and ovarian cystic fluid are almost sterile, although dysbiosis may occur in the vaginal and endometrial microbiome in women with endometriosis.
博士(医学)
http://purl.org/coar/resource_type/c_db06
琉球大学
琉球大学
University of the Ryukyus
2022-03-18
VoR
1445-5781
1447-0578
Reproductive Medicine and Biology
1
21
甲第540号
eng
https://doi.org/10.1002/rmb2.12441
open access
© 2022 The Authors
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.