2024-03-28T18:36:50Z
https://u-ryukyu.repo.nii.ac.jp/oai
oai:u-ryukyu.repo.nii.ac.jp:02019642
2023-08-03T05:37:50Z
1642838163960:1642838338003
1642838403551:1642838407795
Experimental Reconstruction of the Trachea with Urinary Bladder Wall
Chinen, Tetsuji
Hirayasu, Tsuneo
Kuniyoshi, Yukio
Uehara, Kanou
Kinjo, Takao
tracheal reconstruction
tracheal replacement
urinary bladder
bone formation
(ossification)
Purpose: To investigate tracheal reconstruction with autologous bladder wall using modern refined surgical procedures.
Methods: Experiments were performed on 16 female beagle dogs. Six tracheal cartilages were resected to create a tracheal deficit, then tracheal replacement with autologous bladder wall was performed. In the first 10 dogs (first series), the transplant site was covered with pedicled omental flap. In the next six dogs (second series), we performed tracheal reconstruction without omental covering, and secured tracheal cartilages above and below the graft with sutures to prevent excessive graft stretching.
Results: No surgical mortality or lethal infection of the transplant site was encountered in either series. Complications in the first series comprised tracheal stenosis in four dogs. One dog died suddenly at 4 months postoperatively due to stent migration, so cartilage sutures were adopted in the second series. The lumen surface of the grafts was covered with squamous metaplastic epithelium. Osseous tissue was present in the submucosa of grafts, particularly prominently in areas lacking omental covering.
Conclusions: Tracheal reconstruction using bladder wall may become clinically useful. A pedicled omental covering does not appear always necessary to prevent graft necrosis and infection. Ischemic stimulation may be involved with bone formation in grafts.
http://purl.org/coar/resource_type/c_6501
The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
2016
VoR
1341-1098
2186-1005
Annals of Thoracic and Cardiovascular Surgery
3
22
160
153
eng
https://doi.org/10.5761/atcs.oa.15-00375
open access
©2016 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery.
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license.