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  1. 紀要論文
  2. 琉球大学農学部学術報告
  3. 53号
  1. 部局別インデックス
  2. 農学部

ハブ毒免疫したマングースの血中抗体価に関する実験

http://hdl.handle.net/20.500.12000/1227
http://hdl.handle.net/20.500.12000/1227
a72b0161-63f0-4c71-836c-cc89b22fd973
名前 / ファイル ライセンス アクション
01_sakurai.pdf 01_sakurai.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2007-08-02
タイトル
タイトル ハブ毒免疫したマングースの血中抗体価に関する実験
言語 ja
タイトル
タイトル An Experiment on the Antibody Titer in the Blood of Mongoose Immunized with Habn Venom
言語 en
作成者 櫻井, 秀樹

× 櫻井, 秀樹

ja 櫻井, 秀樹

Search repository
川島, 由次

× 川島, 由次

ja 川島, 由次

Search repository
小倉, 剛

× 小倉, 剛

ja 小倉, 剛

Search repository
野崎, 真敏

× 野崎, 真敏

ja 野崎, 真敏

Search repository
香村, 昴男

× 香村, 昴男

ja 香村, 昴男

Search repository
Sakurai, Hideki

× Sakurai, Hideki

en Sakurai, Hideki

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Kawashima, Yoshitugu

× Kawashima, Yoshitugu

en Kawashima, Yoshitugu

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Ogura, Go

× Ogura, Go

en Ogura, Go

Search repository
Nozaki, Masatoshi

× Nozaki, Masatoshi

en Nozaki, Masatoshi

Search repository
Kamura, Takao

× Kamura, Takao

en Kamura, Takao

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 ja
主題Scheme Other
主題 ハブ毒
主題
言語 ja
主題Scheme Other
主題 出血因子1
主題
言語 ja
主題Scheme Other
主題 出血因子2
主題
言語 ja
主題Scheme Other
主題 マングース
主題
言語 ja
主題Scheme Other
主題 ハブ抗毒素
主題
言語 en
主題Scheme Other
主題 habu venom
主題
言語 en
主題Scheme Other
主題 HR-1
主題
言語 en
主題Scheme Other
主題 HR-2
主題
言語 en
主題Scheme Other
主題 mongoose
主題
言語 en
主題Scheme Other
主題 habu antitoxin
内容記述
内容記述タイプ Other
内容記述 A hemorrhagic toxin from habu venom was separated into hemorrhagic factor-1(HR-1) and hemorrhagic factor-2(HR-2) based on the molecular weight of the protein. It is known that the natural inhibitor affecting the neutralization of HR-1 is present in the mongoose serum. However, this natural inhibitor has negligible neutralization activity against HR-2. Therefore, by using habu venom to carry out an immunity test in mongoose, we examined whether any component in the immune serum could be sufficiently effective in neutralizing both HR-1 and HR-2. The habu venom was administered into 10 mongooses for a period of 16 weeks. We drew blood 6 times of during this period and performed exsanguinations 16 weeks later. In this study, we used ELISA to measure the antibody titer for HR-1 and HR-2 in the collected serum. Further, we which we examined habu venom sensitivity in the 10 mongooses and the levels of anti-HR-2 antibody. We compared the results for each mongoose, and, found that there was considerable difference in sensitivity toward the habe venom in each mongoose. In order to evaluate the sensitivity, we used habu antitoxin, which was prepared at the Okinawa prefectural institute of health and environment, in horses and goats. To detect the immune serum component that effectively neutralizes both HR-1 and HR-2 we need to separate the immune serum into its functional components during further investigations, and examine the neutralization activity of the refined serum components in terms of the protein content.
内容記述
内容記述タイプ Other
内容記述 紀要論文
出版者
言語 ja
出版者 琉球大学農学部
言語
言語 jpn
資源タイプ
資源タイプ departmental bulletin paper
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ NA
出版タイプResource http://purl.org/coar/version/c_be7fb7dd8ff6fe43
識別子
識別子 http://hdl.handle.net/20.500.12000/1227
識別子タイプ HDL
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0370-4246
収録物名
言語 ja
収録物名 琉球大学農学部学術報告
収録物名
言語 en
収録物名 The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus
書誌情報
号 53, p. 1-5, 発行日 2006-12
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