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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Helicobacter pylori Induces CCL20 Expression

http://hdl.handle.net/20.500.12000/2447
http://hdl.handle.net/20.500.12000/2447
f1b782a7-7f72-407b-b167-92c8861dbca3
名前 / ファイル ライセンス アクション
Fig2-8.pdf Fig2-8.pdf
Fig.1.pdf Fig.1.pdf
00731-07Ver2.pdf 00731-07Ver2.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2007-11-20
タイトル
タイトル Helicobacter pylori Induces CCL20 Expression
言語 en
作成者 Tomimori, Koh

× Tomimori, Koh

en Tomimori, Koh

Uema, Eriko

× Uema, Eriko

en Uema, Eriko

Teruya, Hiromitsu

× Teruya, Hiromitsu

en Teruya, Hiromitsu

Ishikawa, Chie

× Ishikawa, Chie

en Ishikawa, Chie

Okudaira, Taeko

× Okudaira, Taeko

en Okudaira, Taeko

Senba, Masachika

× Senba, Masachika

en Senba, Masachika

Yamamoto, Kazuo

× Yamamoto, Kazuo

en Yamamoto, Kazuo

Matsuyama, Toshifumi

× Matsuyama, Toshifumi

en Matsuyama, Toshifumi

Kinjo, Fukunori

× Kinjo, Fukunori

en Kinjo, Fukunori

Fujita, Jiro

× Fujita, Jiro

en Fujita, Jiro

Mori, Naoki

× Mori, Naoki

en Mori, Naoki

アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 en
権利情報 Copyright (c) 2007, American Society for Microbiology. All Rights Reserved.
内容記述
内容記述タイプ Other
内容記述 CCL20 attracts immature dendritic cells and memory T cells, and plays a role on mucosal surfaces in inflammation. However, whether H. pylori infection induces CCL20 in human gastric epithelial cells remains to be determined. The aim of this study was to analyze the molecular mechanism of H. pylori-induced CCL20 expression. Expression of CCL20 mRNA was assessed by reverse transcription-PCR. Five normal and five H. pylori-infected gastric tissue samples were stained immunohistochemically for CCL20. Luciferase assay was used to monitor activation of the CCL20 gene promoter, and electrophoretic mobility shift assay was used to explore the binding of transcription factors to this promoter. CCL20 expression in epithelial cells of H. pylori-positive tissues was higher than in H. pylori-negative tissues. H. pylori induced CCL20 expression in gastric epithelial cell lines, and such induction was dependent on an intact cag pathogenicity island. Activation of the CCL20 promoter by H. pylori occurred through the action of NF-κB. Transfection of dominant negative mutants of IκB kinase and NF-κB-inducing kinase inhibited H. pylori-mediated activation of CCL20. Treatment with inhibitor of Hsp90 suppressed H. pylori-induced CCL20 mRNA due to deactivation of NF-κB. Collectively, these results suggest that H. pylori activates NF-κB through an intracellular signaling pathway that involved IκB kinase and NF-κB-inducing kinase, leading to CCL20 gene transcription, and that Hsp90 is a crucial regulator of H. pylori-induced CCL20 expression, presumably contributing to immune response in H. pylori.
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 American Society for Microbiology
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/2447
識別子タイプ HDL
関連情報
関連識別子
識別子タイプ URI
関連識別子 http://iai.asm.org/cgi/content/abstract/75/11/5223
関連識別子
識別子タイプ DOI
関連識別子 10.1128/IAI.00731-07
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0019-9567
収録物識別子タイプ NCID
収録物識別子 AA00673732
収録物名
言語 en
収録物名 Infection and Immunity
書誌情報
巻 75, 号 11, p. 5223-5232
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