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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

Downregulation of citrin, a mitochondrial aspartate glutamate carrier, is associated with apoptosis of hepatocytes

http://hdl.handle.net/20.500.12000/2807
http://hdl.handle.net/20.500.12000/2807
a62310e2-f722-4b0b-8299-4c8ceab1b561
名前 / ファイル ライセンス アクション
Sawada.Fig.pdf Sawada.Fig.pdf
BBRC.Sawada.pdf BBRC.Sawada.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2008-01-04
タイトル
タイトル Downregulation of citrin, a mitochondrial aspartate glutamate carrier, is associated with apoptosis of hepatocytes
言語 en
作成者 Sawada, Shigeki

× Sawada, Shigeki

en Sawada, Shigeki

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Kinjo, Takao

× Kinjo, Takao

en Kinjo, Takao

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Makishi, Shoko

× Makishi, Shoko

en Makishi, Shoko

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Tomita, Mariko

× Tomita, Mariko

en Tomita, Mariko

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Arasaki, Akira

× Arasaki, Akira

en Arasaki, Akira

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Iseki, Kunitoshi

× Iseki, Kunitoshi

en Iseki, Kunitoshi

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Watanabe, Hisami

× Watanabe, Hisami

en Watanabe, Hisami

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Kobayashi, Keiko

× Kobayashi, Keiko

en Kobayashi, Keiko

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Sunakawa, Hajime

× Sunakawa, Hajime

en Sunakawa, Hajime

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Iwamasa, Teruo

× Iwamasa, Teruo

en Iwamasa, Teruo

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Mori, Naoki

× Mori, Naoki

en Mori, Naoki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
言語 en
主題Scheme Other
主題 Apoptosis
主題
言語 en
主題Scheme Other
主題 Caspase
主題
言語 en
主題Scheme Other
主題 Citrullinemia
主題
言語 en
主題Scheme Other
主題 Mitochondria
主題
言語 en
主題Scheme Other
主題 Short hairpin RNA
内容記述
内容記述タイプ Other
内容記述 Citrin is a mitochondrial aspartate glutamate carrier primarily expressed in liver. Adult-onset type II citrullinemia is caused by mutations in the SLC25A13 gene that encodes for citrin, and patients with this condition do not express citrin. We found apoptotic hepatocytes in one such patient. This finding prompted us to investigate the role of citrin in hepatocyte survival. Knockdown of citrin by a vector-based short-hairpin RNA technique reduced cell viability and induced apoptosis of a hepatocellular carcinoma cell line, Hep3B cells. Caspase-3/7 and caspase-9 were activated, and PARP was cleaved. Citrin knockdown also increased the expression of Bax and Bak, and reduced expression of Bcl-xL and Bcl-2. These alterations resulted in the release of cytochrome c from the mitochondria. Our results indicated that citrin downregulation induces apoptosis of hepatocytes through the mitochondrial death pathway, highlighting the importance of citrin in survival of hepatocytes and maintenance of liver function.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
識別子
識別子 http://hdl.handle.net/20.500.12000/2807
識別子タイプ HDL
関連情報
識別子タイプ URI
関連識別子 http://www.sciencedirect.com/science/journal/0006291X
関連情報
識別子タイプ DOI
関連識別子 10.1016/j.bbrc.2007.10.105
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0006-291X
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00564395
収録物名
言語 en
収録物名 Biochemical and Biophysical Research Communications
書誌情報
巻 364, 号 4, p. 937-944
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