@article{oai:u-ryukyu.repo.nii.ac.jp:02002834,
 author = {日越, 博信 and 野口, 蘭子 and 香西, 献 and Higoshi, Hironobu and Noguchi, Ranko and Kouzai, Ken},
 issue = {39},
 journal = {琉球大学農学部学術報告, The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus},
 month = {Dec},
 note = {一養豚場において,肥育豚の導入時(I期)から出荷時(V期)までを5期に分け,約1ヵ月毎に直腸ふん便を採取した。これらふん便由来大腸菌,合計651株について,ABPC, CTC, SM, CP, KM, NA, SAの7薬剤に対する感受性試験を行った。供試大腸菌651株のうち,501株(77.0%)が使用した7薬剤のいずれか1薬剤に耐性であった。時期別にみた耐性菌の検出率は75.0∿78.6%の範囲にあり,ほぼ同じであった。薬剤別では,CTC耐性菌が71.1%で最高,以下SAが40.9%, SMが20.3%, KMが10.9%, ABPCとCPが各5.2%であり,NA耐性菌は検出されなかった。各時期ともCTC, SA, SM, KM耐性菌の検出順位は同じであった。耐性型は,全体では単剤耐性型から6剤耐性型まで29種類認められたが,I期とII期に比べてIII期以降では種類が減少した。また,2剤以上の薬剤に耐性の多剤耐性菌が60.7%を占めたが,III期以降では多剤耐性菌が減少し,単剤耐性菌が増加した。特に,IV期とV期においては,CTC単剤耐性菌が顕著に増加した。耐性菌451株について伝達性Rプラスミドの検索を行ったが,そのうち37株(8.2%)がRプラスミド保有菌であった。伝達耐性型は12種類あり,単剤伝達型が5種類(24株),2剤伝達型が3種類(9株),3剤及び4剤伝達型が各2種類(各2株)であった。, In one pig farm, the period between the introduction and shipment of a fattening pig from various districts of Okinawa was divided into 5 stages. The mean body weight was 32kg in stage I (introduction), 49.9kg in stage II, 73.8kg in stage III, 86.5kg in stage IV and 93.4kg in stage V (shipment period). Feces from the rectum were sampled at monthly intervals for bacteriological examination. The 651 strains of E. coli isolated from these samples were tested for sensitivity to ABPC, CTC, SM, CP, KM, NA and SA. Of the 651 strains, 501 (77.0%) were resistant to 1 of the 7 antibiotics. The rate of detection of resistant bacteria in each stage was between 75.0 and 78.6%. CTC-resistant bacteria were the most common (71.7%) followed by SA-resistant (40.9%), SM-resistant (20.3%), KM-resistant (10.9%) and ABPC- and CP-resistant (5.2% each) strains. No NA-resistant E. coli were detected. In each stage, the order of frequency of detection of strains resistant to CTC, SA, SM, and KM remained the same. Strains resistant to 1 of 6 antibiotics were classified into 29 groups. Compared to stage I and II, the kinds of resistance patterns decreased in after stage III. Initially 60.7% of strains were resistant to more than 2 antibiotics (multi-drug resistance), but after stage III, strains with multi-drug resistance decreased and those resistant to a single antibiotic increased. In stage IV and V, strains resistant to CTC alone were significantly increased. Transmissable R plasmid was found in 37 of 451 strains (8.2%). Twelve types of transmissable resistance were distinguished, 5 to a single antibiotic (24 strains), 3 to 2 antibiotics (9 strains) and 2 each to 3 or 4 antibiotics (2 strains each)., 紀要論文},
 pages = {13--19},
 title = {肥育豚ふん便における薬剤耐性大腸菌の経時的消長(生物生産学科)},
 year = {1992}
}