@article{oai:u-ryukyu.repo.nii.ac.jp:02003337,
 author = {金城, 俊夫 and 仲地, 弘和 and 赤嶺, 幸信 and Kinjo, Toshio and Nakachi, Hirokazu and Akamine, Yukinobu},
 issue = {22},
 journal = {琉球大学農学部学術報告, The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus},
 month = {Dec},
 note = {一般に抗菌剤を含まない飼料で飼育されている健康な牛, 山羊および馬の糞便より分離した大腸菌計986株を対象に, APC, SM, TC, CP, KM, SAの6剤を用いて, 薬剤耐性試験とR因子の検索を行なった。1.牛由来405株中93株, 23.0%が何れかの薬剤に耐性を示す耐性菌であった。耐性菌中, 約半数の46株が単剤耐性菌で, 多剤耐性菌の占める率は比較的低い。耐性パターンではTC(27株), SA(12), TC-SA(7)が主で, これら3型で耐性菌の半数を占めた。2.耐性菌93株中12株, 12.9%にR因子が確認され, SMあるいはAPCを耐性型に持つ多剤耐性菌に比較的高率に検出された。3.山羊由来371株中83株, 22.4%が耐性菌で, うち39株は単剤, 24株は2剤耐性菌であった。主たる耐性パターンはSA, TCおよびAPCの単剤型であったが, 使用した6剤すべてに耐性の株も1株分離された。耐性菌83株中R因子を確認できたのは9株で, 10.8%に相当した。4.馬由来株では, 210株中61株, 29.1%が耐性菌で, 耐性パターンとしてはSA単剤型が最も多く, 次いでAPC-SA, APC型が多く検出された。耐性菌の52.4%が単剤耐性菌である。R因子は6株, 9.8%に検出され, これらは何れも多剤耐性菌に属した。5.上記3家畜由来株に共通した点は, 耐性菌が30%以下, またR因子の検出率も13%以下で共に比較的低率であり, さらに耐性菌の中でも単剤耐性菌が約50%, 2剤耐性菌が約25%を占め, 多剤耐性菌が少ないことであった。薬剤別にみると, SAに対する耐性菌が最も多く, 次いでTC, SM, APCの順で, 逆に, CPおよびKMに対する耐性菌は比較的少数であった。6.以上の成績を, 抗菌剤添加飼料で飼育されている豚および鶏より分離した大腸菌についての, 前報の成績と比較し, 考察を試みた。, A total of 986 fecal E. coli strains isolated from healthy cattle, goats and horses were examined for drug resistance and distribution of R factors. These animals were usually never fed with antimicrobial drug-containing feeds in Okinawa. Of 405 cattle-isolates, 93,or 23.0%, were resistant to one or more drugs used. Thirteen percent (12 strains) of the reistant strains transferred all or a part of their resistance patterns to the sensitive recipient strain. Of the 93 resistant strains, 49.5% were singly resistant and 50.5% were multiply resistant strains. The most common resitant patterns were TC (27 of 93), SA (22 of 93) and TC-SA (7 of 93). Of 371 strains isolated from goats, 83 (22.4%) were found to be resistant. Among the 83 resistant strains, 39,24,12,3 and 1 strains were single-, double-, tripl-, quadruple- and quintuple-resistant, respectively. The SA-resistant strains were isolated most frequently followed by TC- and APC-resistant ones in decreasing order. The R factors were demonstrated at a frequency of 10.8% (9 strains) among 83 resistant strains. Of 210 horse-isolates, 61,or 29.1%, were resistant strains. Among them, 19,8 and 8 strains were SA-, APC-SA- and APC-resistant ones, respectively. Six (9.8%) of the 61 resistant strains were found to carry R factors. In any cases, R factors were demonstrated mostly among multiple resistant strains, particularly, among those possessing SM-reistance pattern. None of CP-resistant strains was found to carry R factors. These results indicated that drug resistant strains and R factors were not so widespread among the animals which were usually not fed with antimicrobial drug-containing feeds., 紀要論文},
 pages = {331--342},
 title = {沖縄の家畜由来細菌の薬剤耐性 : III 牛,山羊および馬糞便由来薬剤耐性大腸菌とその R 因子について(畜産学科)},
 year = {1975}
}