@article{oai:u-ryukyu.repo.nii.ac.jp:02003380, author = {金城, 俊夫 and Kinjo, Toshio}, issue = {21}, journal = {琉球大学農学部学術報告, The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus}, month = {Dec}, note = {沖縄の各地で飼育されている健康な豚および鶏の糞便より大腸菌を分離し, ペニシリン(APC), テトラサイクリン(TC), ストレプトマイシン(SM), クロラムフエニコール(CP), カナマイシン(KM)およびサルフア剤(SA)など6種の薬剤に対する感受性試験を行なった。さらに耐性菌についてはR因子の検出を試みた。得られた成績は次の通りである。1.豚由来152株中147株, 96.7%が耐性菌で, しかも多剤耐性菌が全株の83.6%で高率であった。2.耐性菌147株中65株, 44.2%に伝達可能なR因子が確認された。R因子の耐性型は16種にまたがったが, APC-SM-KMおよびTCの2型が全体の過半数を占めた。3.鶏由来221株中209株, 94.6%が耐性菌であった。多剤耐性菌は79.2%で, うちTC-SM-SAの耐性型を有する3剤耐性菌が100株で,耐性菌の47.8%を示した。4.鶏由来の耐性菌209株中76株(36.4%)がR因子を有しており, その耐性型は9型に分類された。これら耐性型のうちTC, SM, TC-SMの3型が全体の76.3%を占めた。5.豚および鶏由来大腸菌株間に耐性菌の検出頻度およびR因子の分布の状況に差が認められたが, しかし上記の成績より, 沖縄においてもR因子を有する耐性菌が広く分布していることが明らかにされた。, A total of 373 E. coli strains, 152 from pigs and 221 from chickens were surveyed for drug resistance and distribution of R factors. Of 152 pig isolates, only 5 (3.3%) were sensitive to all 6 drugs (APC, TC, SM, CP, KM and SA) used, and other 147 (96.7%) were resistant to one or more drugs. Out of the 147 resistant strains, 65,or 44.2%, were found to transfer all or a part of their resistance patterns to the drug sensitive recipient strain. The resistance patterns of R factors were classified into 16 different patterns, in which 2 patterns, APC-SM-KM and TC, comprised more than 50% of all R factors identified. On the other hand, of 221 strains isolated from chickens, 209 or 94.6%, were drug resistant strains. Seventy-six of the 209 (36.4%) were found to carry R factors, and a total of 9 different patterns of R factors were identified. The most commonly occurring resistance patterns of R factors were patterns of TC, SM, and TC-SM. These 3 patterns of resistance accounted for 76.3% of all R factors detected in chicken isolates. In regard to data of drug resistance and distribution of R factors, there were some differences between strains isolated from pigs and chickens. However, it could be concluded that a high incidence of resistant strains did exist in these animals in Okinawa, and that R factors were widespread among these resistant strains., 紀要論文}, pages = {389--402}, title = {沖縄の家畜由来細菌の薬剤耐性 : II 豚および鶏糞便由来薬剤耐性大腸菌の R 因子について(畜産学科)}, year = {1974} }