@article{oai:u-ryukyu.repo.nii.ac.jp:02003470,
 author = {金城, 俊夫 and Kinjo, Toshio},
 issue = {18},
 journal = {琉球大学農学部学術報告, The Science Bulletin of the Faculty of Agriculture. University of the Ryukyus},
 month = {Dec},
 note = {生後70-120日令の白色レグホン種およびニューハンプシヤー種鶏を用い, Tp感染に対する態度を経口, 心臓, 筋肉および腹腔内など, 接種ルートを変えて比較検討し, 次の如き結果を得た。1.接種ルートの如何に拘わらず, 何れの場合も接種2∿7日目から流血中にTpが現われ, 感染の成立することを認めた。特に経口感染の可能な点興味ある所見である。2.感染鶏はほとんど無症状に耐過する。稀に発症する例では発熱を伴なう元気, 食欲の消失と, 脚麻痺等の症状を呈して斃死し, 各臓器には多数のTpの増殖がみられる。3.血中抗体価は概して低く, 大部分8倍以下である。心臓内接種でほゞ1週間後, 腹腔内接種で2週間後, 筋肉内接種で3週間後にそれぞれ抗体がはじめて検出され, 経口投与ではほとんど抗体の産生が認められず, 接種ルートによってその態度を異にしている。4.一定期間後, 初回に比して大量のTpの再接種を行なうと, 接種部位の組合わせによって成績は幾分趣を異にするが, 初感染によって抗体価は低くても, かなり抵抗性が賦与されていることが明らかである。5.Tpの体内分布状況は接種ルートによって特に異ることなく, 感染後ほぼ1∿2ケ月前後でTpは体内からほとんど消滅されるものと思われる。しかしそれ以後でもなお, チストの型で潜在し, 生体に変調を来たした時, 急激に増殖して生体を発症斃死せしめうる可能性が考えられる。6.剖検上著明な変化を認めたのは比較的少数であったが, 一般に肝における白斑形成が多くみられ, また肝, 脾の腫脹等もかなり多数に認められた。7.産卵開始期に感染を受けた鶏では, 卵巣等を介して卵へTpが移行しやすいように解され, 検索した卵12ケ中3ケの卵黄にTpの移行を確認した。, In this experiment, the behavior of 70-120 day-old chickens against infection with toxoplasma (Tp) was studied. The inoculated routes were those of intra-muscular, -cardiac, -peritoneal and per oral. The results obtained are summarized as follows : 1) Almost all chickens, regardless of their routes of Tp inoculation, showed parasitemia from 2 to 7 days after inoculation. The parasitemia was usually persisted for about 7 days. The fact indicated that Tp is capable to infect chickens per orally. 2) The infected chickens showed no symptoms and kept inapparent infections throughout the experimental periods. However, in a few cases, severe symptoms such as fever reactions and nervous impediments were observed and the chickens died from Tp infection. In such cases, the Tp were detectable directly in stained smear of organs. 3) Antibody titers were usually low such as 1 : 8 or less. The first appearance of antibodies were about 1 week after infection in intra-cardiac injection groups, 2 weeks in intra-peritoneal, and 3 weeks in intra-muscular, respectively. And usually no antibody formation was observed in the groups inoculated per orally. There seemed to exist some correlations between antibody formation and routes of inoculation. 4) Some of chickens were reinoculated with considerable large doses of Tp. Though the results obtained were somewhat different in each case, the chickens generally showed strong resistant to reinoculation regardless of their low antibody titers. However, in 2 cases, severe symptoms were occurred within 1 week. 5) The chickens showed a tendency to clear the parasite from their infected tissues during 1-2 months after inoculation, however, in a few cases, the parasites were proven to persist for a relatively long period without causing the appearance of any symptoms. 6) In autopsy findings, swelling of liver and spleen, and also small white spotted foci of the disease on the surface of liver were mainly observed. But in general, no significant changes were detected in other organs. 7) The Tp were demonstrated in 3 out of 12 eggs laid by such inapparent infected, 2 hens who firstly started to lay eggs after inoculation experiments. The author suggested a possibility that the infected chickens, flesh and eggs may serve as one of sources of toxoplasmic infection for humans and animals., 紀要論文},
 pages = {224--238},
 title = {II. 70-120 日令鶏の感染態度(鶏の実験的トキソプラズマ症に関する研究)(畜産学科)},
 year = {1971}
}