{"created":"2022-01-27T07:51:12.125631+00:00","id":2003984,"links":{},"metadata":{"_buckets":{"deposit":"c88e51b1-fb69-4ee1-9758-9fcd26a9cbe4"},"_deposit":{"id":"2003984","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2003984"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02003984","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makishi, Shoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okudaira, Takeo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishikawa, Chie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawada, Shigeki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watanabe, Toshiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirashima, Mitsuomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sunakawa, Hajime","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mori, Naoki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"galectin-9"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Burkitt lymphoma"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Hodgkin lymphoma"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"NF-κB"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"AP-1"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Identification of galectin-9 as a ligand for T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3), expressed on Th1 cells, has established the Tim-3-galectin-9 pathway as a regulator of Th1 immunity. Whereas there is compelling evidence for the effects of galectin-9 on T-cell fate, limited information is available on the impact of galectin-9 on B lymphocytes. We found that protease-resistant galectin-9, hG9NC(null), but not galectin-1 or -8, prevented cell growth of malignant B cells such as Burkitt lymphoma (BL) and Hodgkin lymphoma (HL). β-galactoside binding was essential for galectin-9-induced cell growth suppression. hG9NC(null) induced cell cycle arrest by reducing the expression of cyclin D1, D2, B1, Cdk4, Cdc25C and c-Myc, and apoptosis by reducing the expression of XIAP, c-IAP2 and survivin. Most of these genes are regulated by nuclear factor-κB (NF-κB), and constitutive activation of NF-κB is a common characteristic of both types of malignancies. hG9NC(null) inhibited IκBα phosphorylation, resulting in suppression of NF-κB. AP-1 has also been implicated in the control of cell survival. hG9NC(null) inhibited the expression of JunD, resulting in the suppression of AP-1. Our results suggest that hG9NC(null) is a potentially suitable agent for the management of BL and HL.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"Blackwell Publishing"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/10319"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0007-1048"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AA00574570"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"British journal of haematology"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"594","bibliographicPageStart":"583","bibliographicVolumeNumber":"142"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"AM","subitem_1600292170262":"http://purl.org/coar/version/c_ab4af688f83e57aa"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"URI","subitem_1522306436033":"http://www3.interscience.wiley.com/journal/120120074/abstract"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"10.1111/j.1365-2141.2008.07229.x"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"BJH53.Fig.Final.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2003984/files/BJH53.Fig.Final.pdf"},"version_id":"3bd7bb2f-48c5-42a2-849e-8bc10365d2aa"},{"accessrole":"open_access","filename":"BJH53.final.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2003984/files/BJH53.final.pdf"},"version_id":"fdcf10a5-8fb2-4fbb-ad39-b1bda5052d94"}]},"item_title":"A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-05-28"},"publish_date":"2009-05-28","publish_status":"0","recid":"2003984","relation_version_is_last":true,"title":["A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:41:41.376728+00:00"}