{"created":"2022-01-27T08:04:09.429870+00:00","id":2004416,"links":{},"metadata":{"_buckets":{"deposit":"984b9259-ea86-4323-a1a4-699f5926e9b6"},"_deposit":{"id":"2004416","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2004416"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02004416","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Machijima, Yoshiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishikawa, Chie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawada, Shigeki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okudaira, Taeko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uchihara, Jun-nosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Yuetsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Taira, Naoya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mori, Naoki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"[Background] Adult T-cell leukemia/lymphoma (ATLL) is a malignancy derived from T cells infected with human T-cell leukemia virus type 1 (HTLV-1), and it is known to be resistant to standard anticancer therapies. Indole-3-carbinol (I3C), a naturally occurring component of Brassica vegetables such as cabbage, broccoli and Brussels sprout, is a promising chemopreventive agent as it is reported to possess antimutagenic, antitumorigenic and antiestrogenic properties in experimental studies. The aim of this study was to determine the potential anti-ATLL effects of I3C both in vitro and in vivo.","subitem_description_type":"Other"},{"subitem_description":"[Results] In the in vitro study, I3C inhibited cell viability of HTLV-1-infected T-cell lines and ATLL cells in a dose-dependent manner. Importantly, I3C did not exert any inhibitory effect on uninfected T-cell lines and normal peripheral blood mononuclear cells. I3C prevented the G1/S transition by reducing the expression of cyclin D1, cyclin D2, Cdk4 and Cdk6, and induced apoptosis by reducing the expression of XIAP, survivin and Bcl-2, and by upregulating the expression of Bak. The induced apoptosis was associated with activation of caspase-3, -8 and -9, and poly(ADP-ribose) polymerase cleavage. I3C also suppressed IkappaB-alpha phosphorylation and JunD expression, resulting in inactivation of NF-kappaB and AP-1. Inoculation of HTLV-1-infected T cells in mice with severe combined immunodeficiency resulted in tumor growth. The latter was inhibited by treatment with I3C (50 mg/kg/day orally), but not the vehicle control.","subitem_description_type":"Other"},{"subitem_description":"[Conclusion] Our preclinical data suggest that I3C could be potentially a useful chemotherapeutic agent for patients with ATLL.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"BioMed Central Ltd."}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/8827"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1742-4690"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AA12051445"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Retrovirology"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"7","bibliographicVolumeNumber":"6"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"AM","subitem_1600292170262":"http://purl.org/coar/version/c_ab4af688f83e57aa"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"URI","subitem_1522306436033":"http://www.retrovirology.com/content/6/1/7"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"10.1186/1742-4690-6-7"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"Machijima.Fig.RV.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2004416/files/Machijima.Fig.RV.pdf"},"version_id":"1ea52c0c-56c6-4753-9944-7df46343fa55"},{"accessrole":"open_access","filename":"msMori.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2004416/files/msMori.pdf"},"version_id":"9b28f437-b2b2-4717-bd71-d076f2fe72ab"}]},"item_title":"Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-01-19"},"publish_date":"2009-01-19","publish_status":"0","recid":"2004416","relation_version_is_last":true,"title":["Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:34:54.606775+00:00"}