{"created":"2022-01-27T08:05:14.702588+00:00","id":2004442,"links":{},"metadata":{"_buckets":{"deposit":"97f9242f-6b6e-4bf9-9a41-3529a750a94b"},"_deposit":{"id":"2004442","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2004442"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02004442","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Application of Signal Transduction Inhibition as a Therapeutic Strategy for Adult T-Cell Leukemia.","subitem_1551255648112":"en"},{"subitem_1551255647225":"シグナル伝達経路の阻害による成人T細胞白血病（ATL）の治療戦略","subitem_1551255648112":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori, Naoki","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"adult T-cell leukemia"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"human T-cell leukemia virus type 1"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"signal transduction"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"apoptosis"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"IRPC（International Research Promotion Council：国際研究振興協議会）が授与しているEminent Scientist of the Year 2007（Hematology Oncology and Medical Virology部門）の受賞研究","subitem_description_type":"Other"},{"subitem_description":"再掲：Recent Advances and Research Updates, 9, p.47-58, 2008","subitem_description_type":"Other"},{"subitem_description":"再掲：Austral-Asian Journal of Cancer, Vol.7 No.2, April 2008","subitem_description_type":"Other"},{"subitem_description":"[Abstract]Adult T-cell leukemia (ATL) is a fatal malignancy of T lymphocytes caused by human T-cell leukemia virus type 1 (HTLV-1) infection, and remains incurable. Until recently, only a few effective therapies existed. Therefore, continued efforts to develop new therapies are needed. During the last decade, rapid progress has been made in our understanding of the molecular pathways underlying the proliferation of HTLV-1-infected T cells. The processes by which messages initiate protein synthesis, cell cycle progression, and even cell death are transmitted from the cell surface or the cytoplasm to the nucleus are broadly referred to as “signal transduction”. These multistep pathways involve a host of proteins that interact with other proteins in overlapping cascades that flow downstream in a stepwise fashion from the cell membrane to the nucleus. Inappropriate overactivation or underactivation of various components of such signaling pathways can contribute to pathological processes, such as neoplasia. Conversely, molecular and pharmacological interventions that target and attempt to reverse the aberrant state of activation can be potentially of therapeutic benefits. We review the contribution of signal transduction pathways including nuclear factor-kappa B, activator protein-1, janus kinase-signal transducer and activator of transcription, and phosphatidylinositol 3-kinase-Akt to the pathogenesis of ATL and the methods by which targeted inhibition of selected signaling pathway components has been exploited to inhibit the growth of HTLV-1-infected T cells both in vitro and in vivo. The potential translation of such strategies into effects therapies for patients with ATL may improve the poor outcome associated with this neoplasia.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"International Research Promotion Council"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/9407"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0972-4699"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Recent Advances and Research Updates"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"288","bibliographicPageStart":"277","bibliographicVolumeNumber":"8"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"mori-corrected.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2004442/files/mori-corrected.pdf"},"version_id":"ea191437-d3c1-4be4-8301-5d98d66fa5c7"}]},"item_title":"Application of Signal Transduction Inhibition as a Therapeutic Strategy for Adult T-Cell Leukemia.","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-26"},"publish_date":"2009-03-26","publish_status":"0","recid":"2004442","relation_version_is_last":true,"title":["Application of Signal Transduction Inhibition as a Therapeutic Strategy for Adult T-Cell Leukemia."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:34:56.440892+00:00"}