{"created":"2022-01-28T01:00:37.571970+00:00","id":2005067,"links":{},"metadata":{"_buckets":{"deposit":"d6ccfa16-10cf-4b94-a0ac-8c9186efb86e"},"_deposit":{"id":"2005067","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2005067"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02005067","sets":["1642838403123","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"新規アポトーシス抑制因子によるマラリア原虫感染での病態修飾機構の解析","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Apoptosis inhibitor expressed by macrophages regulates the murine malaria development","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡部, 久実","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Watanabe, Hisami","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"ネズミマラリア原虫"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"自然免疫機構"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"アポトーシス抑制因子"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"マクロファージ"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"原虫の排除"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"貪食能亢進"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"炎症性サイトカイン"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"抗炎症性サイトカイン"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"科研費番号: 19590433","subitem_description_type":"Other"},{"subitem_description":"2007年度～2008年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"},{"subitem_description":"研究概要：本研究では、自然免疫担当細胞であるマクロファージ(MФ)が産生する新規アポトーシス抑制因子(AIM)を欠損するマウスを用い、マラリア原虫感染におけるNKT細胞及びγδT細胞の活性化機能制御とMФの関係を明らかにし、新しい視点での感染防御機構だけでなく病態形成の機序について検討を加えた。その結果、マラリア感染症においては、MФの機能としての貪食作用による病原体の排除やそれに伴う炎症反応の惹起にAIMが深く関与しており、その機能制御が予防・治療に有効である可能性が示唆された。","subitem_description_type":"Other"},{"subitem_description":"研究報告書","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"渡部久実"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/13528"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"}}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"AM","subitem_1600292170262":"http://purl.org/coar/version/c_ab4af688f83e57aa"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"19590433seika.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2005067/files/19590433seika.pdf"},"version_id":"51e99966-c374-42e5-bb74-7e6c0d61fc80"}]},"item_title":"新規アポトーシス抑制因子によるマラリア原虫感染での病態修飾機構の解析","item_type_id":"15","owner":"1","path":["1642838403123","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-12-01"},"publish_date":"2009-12-01","publish_status":"0","recid":"2005067","relation_version_is_last":true,"title":["新規アポトーシス抑制因子によるマラリア原虫感染での病態修飾機構の解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T02:28:46.269876+00:00"}