{"created":"2022-01-28T01:03:18.501623+00:00","id":2005153,"links":{},"metadata":{"_buckets":{"deposit":"fbe636f1-a77e-4c65-92e2-3a884748e963"},"_deposit":{"id":"2005153","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2005153"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02005153","sets":["1642838403123","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"Strongyloides venezuelensisを用いた糞線虫感染防御免疫の研究","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Studies on the protective immunity to Strongyloides infection in mice infected with S. venezuelensis","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 良也","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Sato, Yoshiya","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"寄生虫病"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"糞線虫症"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"ベネゼラ糞線虫"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"感染防御免疫"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"インターロイキン5"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"ヌードマウス"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"parasitic infection"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"strongyloidiasis"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Strongyloides venezuelensis"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"protective immunity"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"nude mouse"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"IL-5"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"susceptibility"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"科研費番号: 01570218","subitem_description_type":"Other"},{"subitem_description":"平成2年度科学研究費補助金(一般研究C)研究成果報告書","subitem_description_type":"Other"},{"subitem_description":"研究概要:ベネゼラ糞線虫は、本来ラットの糞線虫であるがマウスにも感染する。本研究では、ベネゼラ糞線虫－マウス感染モデルが、従来のネズミ糞線虫に比べ、ヒトにおける糞線虫症の研究にとって優れた感染モデルであることを明らかにした。即ち、ベネゼラ糞線虫はネズミ糞線虫に比べてマウスに対して高い感染性を示すこと、感染後の体内移行経路がヒトの糞線虫のそれに類似することなどが利点としてあげられる。しかしながら、マウスでの感染成立は一過性であり、消化管内の成虫はやがて排除される。その後、このマウスには再感染に対する強い抵抗性が誘導される。胸腺を欠損するヌードマウスでは、このような成虫の排虫現象も再感染に対する防御も認められず、これらの現象はいずれもTリンパ球に依存性の免疫学的イベントであることが明らかとなった。これらの感染防御能は有毛+/+マウスの脾細胞によってヌードマウスに移入することができたが、感染血清による防御免疫の移入はできなかった。防御反応におけるインターロイキン 5の役割を検討するために、抗－IL5モノクローン抗体を投与したマウスにベネゼラ糞線虫を感染させたところ、成虫の消化管からの排除反応には影響がみられらなかったが、再感染幼虫に対する防御効果はこのモノクローン抗体処理によって著明に減弱した。これらのことから、成虫の排虫現象と体内移行期の幼虫に対する殺滅作用は、各々異なる免疫メカニズムによって担われており、前者はIL-5非依存性であるが、後者はIL-5依存性であると判断された。","subitem_description_type":"Other"},{"subitem_description":"要約(欧文):Strongyloides venezuelensis is a rodent parasite which is infective to mice. In the present study, the murine infection model with S. venezuelensis was found to be a more useful model for the study of human strongyloidiasis than that with S. ratti, because S. venezuelensis is much more infective to mice and also because the migratory route in mice may be comparable to that of S. stercoralis in humans. The mice infected with S. venezuelensis were also found to aquire an almost complete resistance to the secondary infection after expulsion of intestinal adults of the primary infection. Unlike the immunocompetent nu/+ mice, the hypothymic nude (nu/nu) mice were unable to expel the adult worms and no aquired resistance to rechallenge was observed among them. The expulsion of adult worm, as well as the resistance against migratory larvae in the secondary infection, were transferrable to nude mice by spleen cells from intact nu/+ mice, but not by infected serum. These results support the hypothesis that direct worm immunity and worm expulsion are a T cell-dependent phenomenon. In another experiment in which inetrleukin-5 (IL-5) was depleted by treatment with anti-IL-5 monoclonal antibodies, the anti-IL-5 treatment did not affect worm burden and faecal egg output after primary infection. However, when mice were treated after expulsion of intestinal adults, the worm recovery from lungs after the secondary infection was the same as that in the primary infection. The results suggested that the host's protective immunity against tissuemigrating larvae was IL-5-dependent but intestinal immunity was not.","subitem_description_type":"Other"},{"subitem_description":"未公開：P.27以降(別刷論文のため)","subitem_description_type":"Other"},{"subitem_description":"研究報告書","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"佐藤良也"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/13991"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"}}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"01570218.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2005153/files/01570218.pdf"},"version_id":"8269c7b4-42bf-499c-a2b4-40b2fa8c392e"}]},"item_title":"Strongyloides venezuelensisを用いた糞線虫感染防御免疫の研究","item_type_id":"15","owner":"1","path":["1642838403123","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-12-16"},"publish_date":"2009-12-16","publish_status":"0","recid":"2005153","relation_version_is_last":true,"title":["Strongyloides venezuelensisを用いた糞線虫感染防御免疫の研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T02:30:44.290900+00:00"}