{"created":"2022-01-28T01:03:20.102785+00:00","id":2005154,"links":{},"metadata":{"_buckets":{"deposit":"458cc459-3efd-46ac-9cb0-8b64571a8f73"},"_deposit":{"id":"2005154","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2005154"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02005154","sets":["1642838403123","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"ATLウイルスの混合感染が糞線虫症の治療効果に及ぼす影響に関する免疫学的研究","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Immunological studies on effect of concurrent HTLV-I infection on efficacy of treatment of strongyloidiasis","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 良也","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"當真, 弘","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"小林, 潤","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Sato, Yoshiya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toma, Hiromu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Jun","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"糞線虫症"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"日和見感染"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"ATL"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"HTLV-I"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"治療効果"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"免疫応答"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"strongyloidiasis"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Strongyloides stercoralis"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"adult T-cell leukemia (ATL)"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"therapeutic efficacy"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"immune response"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"科研費番号: 04670234","subitem_description_type":"Other"},{"subitem_description":"平成5年度科学研究費補助金(一般研究C)研究成果報告書","subitem_description_type":"Other"},{"subitem_description":"研究概要:200名を超える糞線虫保有者を3種類の薬剤で各々治療し、いずれの場合にもHTLV-I陽性の患者での治癒率が著明に低いことを確認した。HTLV-I 陽性者での治癒率の低下はポキールのような治療効果の比較的低い薬剤を使用した場合に特に著明であった。この結果をもとに、治療前の各種免疫学的検査所見と治療効果との関連を検討した。その結果、血清中の抗－糞線虫抗体値と治療効果との間には何ら関連性を見いだすことができず、HTLV-I感染と抗体値の間にも明らかな関連はなかった。また、血清総IgE値や末梢血での好酸球比率はHTLV-I感染者でやや低い傾向を示し、それらと治療効果との関連では IgE値が治癒群でやや高かったのに対し、好酸球反応は未治癒群で増加傾向にあるという結果を得た。しかし、未治癒群で好酸球増多傾向が見られたことは、これら未治癒群で感染が増悪傾向にあり、これが好酸球反応を強く刺激した結果と考えられ、治療効果と好酸球の関連を必ずしも否定するものではなかった。他方、末梢血のリンパ球はやはり未治癒群においてヘルパ－T細胞の相対的増加傾向、活性化T細胞の増加傾向を示した。しかし、これらの結果はHTLV-I感染者において一般に強く求められる所見であり、未治癒群ではHTLV-I陽性者が多くみられることを反映した結果と判断された。HTLV-Iの感染状態を示す異型リンパ球の出現頻度と治療効果との関連では、未治癒群においてやや異型リンパ球の出現頻度が高い傾向にあったが、その差は大きなものではなかった。本研究をとおして得られた結果は、当初予想したような治療効果の低下と免疫不全状態を関連づけるものではなかった。その原因のひとつは、血清抗体値の検討を除けば今回検討した内容が糞線虫に対して特異的なものではなく、また、比較的効果の低いポキール治療を対象としたためと考えられた。","subitem_description_type":"Other"},{"subitem_description":"要約(欧文):A total of 206 patients with strongyloidiasis were treated with pyrvinium pamoate, thiabendazole and albendazole. The therapeutic efficacy by these anthelmintics was significantly lower in the patients with concurrent HTLV-I infection. The difference in efficacy was most significant in pyrvinium pamoate treatment which is less effective for treatment of strongyloidiasis. The relationship between immunological findings and the therapeutic efficacy in the patients was examined as follows. There was no difference in anti-Strongyloides antibody levels between the two groups with different therapeutic efficacy. Eosinophil counts in peripheral blood were relatively lower in the cured group and total serum IgE levels were higher in the same group, although the difference was not so significant. The higher level of perihperal eosinohpils was considered to be due to a relatively severe infection which might result in unsuccessful treatment, rather than the depressed eosinophil response in the cured group. When peripheral lymphocyte subsets were compared similarly, relative increase of helper and activated T-cell subsets were observed in the unsuccessfully treated group. The results, however, appeared to be due to HTLV-I infection among many patients in the group of unsuccessful treatment, because these subsets are known to increase in the HTLV-I carriers. The presence of atypical lymphocytes in peripheral blood was more frequent in the \"unsuccessful treatment\" group but the frequency was not different so significantly from the \"cured\" group. The results obtained could not determine the depressed immune responses in group resistant to anthelmintic treatment, as it was speculated in the start of this study. In order to clarify the relationship between immune status and therapeutic efficacy, the immune response specific for Strongyloides should be further examined in treatment with more effective anthelmintics for strongyloidiasis.","subitem_description_type":"Other"},{"subitem_description":"未公開：P.16以降(別刷論文のため)","subitem_description_type":"Other"},{"subitem_description":"研究報告書","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"佐藤良也"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/13989"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"NCID","subitem_1522646572813":"BA64166175"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03","bibliographicIssueDateType":"Issued"}}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"04670234.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2005154/files/04670234.pdf"},"version_id":"1b563ba5-b83e-4d31-a1ff-f1757cff82fd"}]},"item_title":"ATLウイルスの混合感染が糞線虫症の治療効果に及ぼす影響に関する免疫学的研究","item_type_id":"15","owner":"1","path":["1642838403123","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-12-16"},"publish_date":"2009-12-16","publish_status":"0","recid":"2005154","relation_version_is_last":true,"title":["ATLウイルスの混合感染が糞線虫症の治療効果に及ぼす影響に関する免疫学的研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-10-31T02:30:46.423066+00:00"}