{"created":"2022-01-28T07:18:27.524868+00:00","id":2008836,"links":{},"metadata":{"_buckets":{"deposit":"a6be01af-bf63-42dd-9c8c-d036daa58e1d"},"_deposit":{"id":"2008836","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2008836"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02008836","sets":["1642838163960:1642838338003","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"乳がん細胞への細胞毒性に及ぼす脂肪酸の炭素鎖構造の影響","subitem_1551255648112":"ja"},{"subitem_1551255647225":"Effects of Carbon Chain Structures of Fatty Acids on Their Cytotoxicity to Breast Cancer Cells","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wongtangtintharn, Sawitree","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"屋, 宏典","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"稲福, 征志","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"岩崎, 公典","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"戸田, 隆義","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"Wongtangtintharn, Sawitree","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Oku, Hirosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inafuku, Masashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwasaki, Hironori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toda, Takayoshi","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"分枝鎖脂肪酸"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"化学構造"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"炭素鎖"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"乳がん細胞"},{"subitem_1522299896455":"ja","subitem_1522300014469":"Other","subitem_1523261968819":"細胞毒性"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"branched chain fatty acid"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"chemical structure"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"carbon chain"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"breast cancer cell"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"cytotoxicity"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"分枝鎖脂肪酸の抗がん活性の発現メカニズムを探るため，特殊な炭素鎖構造をもっ脂肪酸の乳がん細胞脂質への取り込みを調べ，脂肪酸炭素鎖の化学構造と細胞毒性との関連性について検討した。培地に添加されたすべての脂肪酸はリン脂質よりもトリグリセリドに優先的に取り込まれ，分枝鎖脂肪酸については主鎖の炭素数が14の脂肪酸が13のものよりも取り込み率が高い傾向にあった。シクロアルキル基をもっ脂肪酸の取り込みは分枝鎖脂肪酸よりも低い傾向にあった。ヒドロキシ脂肪酸の取り込みは分校鎖脂肪酸とほぼ同程度と見積もられた。分枝鎖脂肪酸のD50 は他の脂肪酸よりも低い傾向にあり，シクロアルキル基をもっ脂肪酸およびヒドロキシ脂肪酸のD50 は直鎖脂肪酸と同程度か高い傾向にあった。主鎖の炭素数は同一で化学構造が異なる脂肪酸の細胞毒性を比較すると，分枝鎖脂肪酸についてのみ乳がん細胞に対する細胞毒性が認められ，分校鎖の化学構造が細胞毒性と関連していることが示唆された。","subitem_description_type":"Other"},{"subitem_description":"This study investigated the incorporation of unusual fatty acids into cellular lipids of breast cancer cells and its relevance to cell cytotoxicity. Fatty acids added to the culture medium were preferentially incorporated into triacylglycero1s rather than into phospholipids. The length of the main carbon chain appeared to be the critical factor for incorporation into cellular lipids. Incorporation of branched-chain fatty acids was higher than that of cycloalkyl fatty acids，and similar to that of hydroxy fatty acids. The cytotoxicities of branched-chain fatty acids were stronger than those of cycloalkyl or hydroxy fatty acids.Thus，of the fatty acids studied，only branched-chain fatty acids exhibited cytotoxicity against breast cancer cells. These observations suggest that the branched carbon chain structure has some relevance to its cytotoxicity.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"ja","subitem_1522300316516":"公益社団法人日本栄養・食糧学会"},{"subitem_1522300295150":"en","subitem_1522300316516":"Japan Society of Nutrition and Food Science"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"jpn"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/37608"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1883-2849"},{"subitem_1522646500366":"NCID","subitem_1522646572813":"AN00311992"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"ja","subitem_1522650091861":"日本栄養・食糧学会誌"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"118","bibliographicPageStart":"115","bibliographicVolumeNumber":"59"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.4327/jsnfs.59.115"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"info:doi/10.4327/jsnfs.59.115"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"vol59no2p115.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2008836/files/vol59no2p115.pdf"},"version_id":"931db694-2a65-4db1-b5ac-4d683e3e7a78"}]},"item_title":"乳がん細胞への細胞毒性に及ぼす脂肪酸の炭素鎖構造の影響","item_type_id":"15","owner":"1","path":["1642838338003","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-29"},"publish_date":"2018-01-29","publish_status":"0","recid":"2008836","relation_version_is_last":true,"title":["乳がん細胞への細胞毒性に及ぼす脂肪酸の炭素鎖構造の影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:41:21.982588+00:00"}