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TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits antimycobacterial macrophage activation

http://hdl.handle.net/20.500.12000/50025
http://hdl.handle.net/20.500.12000/50025
ad11232b-7e27-47c2-84ac-e37bdb0f4ea3
名前 / ファイル ライセンス アクション
s41467-021-22620-3.pdf s41467-021-22620-3.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2021-11-16
タイトル
タイトル TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits antimycobacterial macrophage activation
言語 en
作成者 Iizasa, Ei'ichi

× Iizasa, Ei'ichi

en Iizasa, Ei'ichi

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Chuma, Yasushi

× Chuma, Yasushi

en Chuma, Yasushi

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Uematsu, Takayuki

× Uematsu, Takayuki

en Uematsu, Takayuki

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Kubota, Mio

× Kubota, Mio

en Kubota, Mio

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Kawaguchi, Hiroaki

× Kawaguchi, Hiroaki

en Kawaguchi, Hiroaki

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Umemura, Masayuki

× Umemura, Masayuki

en Umemura, Masayuki

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Toyonaga, Kenji

× Toyonaga, Kenji

en Toyonaga, Kenji

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Kiyohara, Hideyasu

× Kiyohara, Hideyasu

en Kiyohara, Hideyasu

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Yano, Ikuya

× Yano, Ikuya

en Yano, Ikuya

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Colonna, Marco

× Colonna, Marco

en Colonna, Marco

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Sugita, Masahiko

× Sugita, Masahiko

en Sugita, Masahiko

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Matsuzaki, Goro

× Matsuzaki, Goro

en Matsuzaki, Goro

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Yamasaki, Sho

× Yamasaki, Sho

en Yamasaki, Sho

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Yoshida, Hiroki

× Yoshida, Hiroki

en Yoshida, Hiroki

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Hara, Hiromitsu

× Hara, Hiromitsu

en Hara, Hiromitsu

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © The Author(s) 2021
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
権利情報
言語 en
権利情報Resource http://creativecommons.org/ licenses/by/4.0/
権利情報 http://creativecommons.org/ licenses/by/4.0/
内容記述
内容記述タイプ Other
内容記述 Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and latency; however, a mechanism of action is unclear. Here, we show that the DAP12-associated triggering receptor expressed on myeloid cells 2 (TREM2) recognizes mycobacterial cell-wall mycolic acid (MA)-containing lipids and suggest a mechanism by which mycobacteria control host immunity via TREM2. Macrophages respond to glycosylated MA-containing lipids in a Mincle/FcRγ/CARD9-dependent manner to produce inflammatory cytokines and recruit inducible nitric oxide synthase (iNOS)-positive mycobactericidal macrophages. Conversely, macrophages respond to non-glycosylated MAs in a TREM2/DAP12-dependent but CARD9-independent manner to recruit iNOS-negative mycobacterium-permissive macrophages. Furthermore, TREM2 deletion enhances Mincle-induced macrophage activation in vitro and inflammation in vivo and accelerates the elimination of mycobacterial infection, suggesting that TREM2-DAP12 signaling counteracts Mincle-FcRγ-CARD9-mediated anti-mycobacterial immunity. Mycobacteria, therefore, harness TREM2 for immune evasion. Download PDF
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Springer Nature
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/50025
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41467-021-22620-3
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41467-021-22620-3
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2041-1723
収録物名
言語 en
収録物名 Nature Communications
書誌情報
巻 12, 発行日 2021-04-16
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