@article{oai:u-ryukyu.repo.nii.ac.jp:02011038,
 author = {Iizasa, Ei'ichi and Chuma, Yasushi and Uematsu, Takayuki and Kubota, Mio and Kawaguchi, Hiroaki and Umemura, Masayuki and Toyonaga, Kenji and Kiyohara, Hideyasu and Yano, Ikuya and Colonna, Marco and Sugita, Masahiko and Matsuzaki, Goro and Yamasaki, Sho and Yoshida, Hiroki and Hara, Hiromitsu},
 journal = {Nature Communications},
 month = {Apr},
 note = {Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and latency; however, a mechanism of action is unclear. Here, we show that the DAP12-associated triggering receptor expressed on myeloid cells 2 (TREM2) recognizes mycobacterial cell-wall mycolic acid (MA)-containing lipids and suggest a mechanism by which mycobacteria control host immunity via TREM2. Macrophages respond to glycosylated MA-containing lipids in a Mincle/FcRγ/CARD9-dependent manner to produce inflammatory cytokines and recruit inducible nitric oxide synthase (iNOS)-positive mycobactericidal macrophages. Conversely, macrophages respond to non-glycosylated MAs in a TREM2/DAP12-dependent but CARD9-independent manner to recruit iNOS-negative mycobacterium-permissive macrophages. Furthermore, TREM2 deletion enhances Mincle-induced macrophage activation in vitro and inflammation in vivo and accelerates the elimination of mycobacterial infection, suggesting that TREM2-DAP12 signaling counteracts Mincle-FcRγ-CARD9-mediated anti-mycobacterial immunity. Mycobacteria, therefore, harness TREM2 for immune evasion.  Download PDF, 論文},
 title = {TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits antimycobacterial macrophage activation},
 volume = {12},
 year = {2021}
}