{"created":"2022-02-01T05:36:15.829383+00:00","id":2011038,"links":{},"metadata":{"_buckets":{"deposit":"b9a82647-0c96-4831-bd56-c5114954626c"},"_deposit":{"id":"2011038","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2011038"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02011038","sets":["1642838163960:1642838338003","1642838403551:1642838412624"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits antimycobacterial macrophage activation","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iizasa, Ei'ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chuma, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uematsu, Takayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kubota, Mio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Hiroaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Umemura, Masayuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toyonaga, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kiyohara, Hideyasu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yano, Ikuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Colonna, Marco","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sugita, Masahiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuzaki, Goro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamasaki, Sho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshida, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hara, Hiromitsu","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"ja","subitem_1522651041219":"© The Author(s) 2021"},{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution 4.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"http://creativecommons.org/ licenses/by/4.0/","subitem_1522651041219":"http://creativecommons.org/ licenses/by/4.0/"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and latency; however, a mechanism of action is unclear. Here, we show that the DAP12-associated triggering receptor expressed on myeloid cells 2 (TREM2) recognizes mycobacterial cell-wall mycolic acid (MA)-containing lipids and suggest a mechanism by which mycobacteria control host immunity via TREM2. Macrophages respond to glycosylated MA-containing lipids in a Mincle/FcRγ/CARD9-dependent manner to produce inflammatory cytokines and recruit inducible nitric oxide synthase (iNOS)-positive mycobactericidal macrophages. Conversely, macrophages respond to non-glycosylated MAs in a TREM2/DAP12-dependent but CARD9-independent manner to recruit iNOS-negative mycobacterium-permissive macrophages. Furthermore, TREM2 deletion enhances Mincle-induced macrophage activation in vitro and inflammation in vivo and accelerates the elimination of mycobacterial infection, suggesting that TREM2-DAP12 signaling counteracts Mincle-FcRγ-CARD9-mediated anti-mycobacterial immunity. Mycobacteria, therefore, harness TREM2 for immune evasion.  Download PDF","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"Springer Nature"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/50025"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"2041-1723"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"Nature Communications"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04-16","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"12"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1038/s41467-021-22620-3"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1038/s41467-021-22620-3"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"s41467-021-22620-3.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2011038/files/s41467-021-22620-3.pdf"},"version_id":"7b55f9eb-7d3d-4f1f-bf15-3413396e5298"}]},"item_title":"TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits antimycobacterial macrophage activation","item_type_id":"15","owner":"1","path":["1642838338003","1642838412624"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-16"},"publish_date":"2021-11-16","publish_status":"0","recid":"2011038","relation_version_is_last":true,"title":["TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits antimycobacterial macrophage activation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:43:19.662988+00:00"}