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  1. 学術雑誌論文
  2. その他
  1. 部局別インデックス
  2. 医学部

The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction–diffusion system

http://hdl.handle.net/20.500.12000/50051
http://hdl.handle.net/20.500.12000/50051
6e635a7f-2678-48c8-bf70-49bc117650ed
名前 / ファイル ライセンス アクション
s41598-021-84653-4.pdf s41598-021-84653-4.pdf
Item type デフォルトアイテムタイプ(フル)(1)
公開日 2021-11-17
タイトル
タイトル The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction–diffusion system
言語 ja
作成者 Kataoka, Keiichi

× Kataoka, Keiichi

en Kataoka, Keiichi

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Fujita, Hironori

× Fujita, Hironori

en Fujita, Hironori

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Isa, Mutsumi

× Isa, Mutsumi

en Isa, Mutsumi

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Gotoh, Shimpei

× Gotoh, Shimpei

en Gotoh, Shimpei

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Arasaki, Akira

× Arasaki, Akira

en Arasaki, Akira

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Ishida, Hajime

× Ishida, Hajime

en Ishida, Hajime

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Kimura, Ryosuke

× Kimura, Ryosuke

en Kimura, Ryosuke

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
言語 ja
権利情報 © The Author(s) 2021
権利情報
言語 en
権利情報 Creative Commons Attribution 4.0
権利情報
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 https://creativecommons.org/licenses/by/4.0/
内容記述
内容記述タイプ Other
内容記述 Morphological variations in human teeth have long been recognized and, in particular, the spatial and temporal distribution of two patterns of dental features in Asia, i.e., Sinodonty and Sundadonty, have contributed to our understanding of the human migration history. However, the molecular mechanisms underlying such dental variations have not yet been completely elucidated. Recent studies have clarified that a nonsynonymous variant in the ectodysplasin A receptor gene (EDAR 370V/A; rs3827760) contributes to crown traits related to Sinodonty. In this study, we examined the association between the EDAR polymorphism and tooth root traits by using computed tomography images and identified that the effects of the EDAR variant on the number and shape of roots differed depending on the tooth type. In addition, to better understand tooth root morphogenesis, a computational analysis for patterns of tooth roots was performed, assuming a reaction–diffusion system. The computational study suggested that the complicated effects of the EDAR polymorphism could be explained when it is considered that EDAR modifies the syntheses of multiple related molecules working in the reaction–diffusion dynamics. In this study, we shed light on the molecular mechanisms of tooth root morphogenesis, which are less understood in comparison to those of tooth crown morphogenesis.
内容記述
内容記述タイプ Other
内容記述 論文
出版者
言語 en
出版者 Springer Nature
言語
言語 eng
資源タイプ
資源タイプ journal article
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
識別子
識別子 http://hdl.handle.net/20.500.12000/50051
識別子タイプ HDL
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-021-84653-4
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-021-84653-4
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2045-2322
収録物名
言語 en
収録物名 Scientific Reports
書誌情報
巻 11, 号 1, 発行日 2021-03
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