{"created":"2022-02-01T06:34:26.946457+00:00","id":2011104,"links":{},"metadata":{"_buckets":{"deposit":"d5cb8530-e8ac-4476-ac1c-aea45b45b3ad"},"_deposit":{"id":"2011104","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2011104"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02011104","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_30002_access_rights4":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30002_bibliographic_information29":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicVolumeNumber":"13"}]},"item_30002_creator2":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Taira, Makiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Imamura, Minako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Atsushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamatani, Yoichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamauchi, Toshimasa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Araki, Shin-ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Nobue","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"van Zuydam, Natalie R.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ahlqvist, Emma","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toyoda, Masao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Umezono, Tomoya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawai, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Imanishi, Masahito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watada, Hirotaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Daisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maegawa, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Babazono, Tetsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kaku, Kohei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kawamori, Ryuzo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Groop, Leif C.","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"McCarth, Mark, I","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kadowaki, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maeda, Shiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"The SUMMIT Consortium","creatorNameLang":"en"}]}]},"item_30002_description9":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 x 10^<-4>) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 x 10^<-10>. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 x 10^<-10>). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_30002_file35":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"journal.pone.0208654.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2011104/files/journal.pone.0208654.pdf"},"version_id":"b764e6bc-1a97-4426-976a-c0b4b4423cc7"}]},"item_30002_identifier16":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/46886"}]},"item_30002_language12":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30002_publisher10":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science","subitem_publisher_language":"en"}]},"item_30002_relation18":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0208654","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0208654","subitem_relation_type_select":"DOI"}}]},"item_30002_resource_type13":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_30002_rights6":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en"},{"subitem_rights":"https://creativecommons.org/licenses/by/4.0/","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by/4.0/"}]},"item_30002_source_identifier22":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_30002_source_title23":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_source_title":"PLOS ONE","subitem_source_title_language":"en"}]},"item_30002_title0":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes","subitem_title_language":"en"}]},"item_30002_version_type15":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes","item_type_id":"30002","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-07"},"publish_date":"2020-10-07","publish_status":"0","recid":"2011104","relation_version_is_last":true,"title":["A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2025-02-18T11:27:31.051023+00:00"}