{"created":"2022-02-01T06:35:18.109428+00:00","id":2011130,"links":{},"metadata":{"_buckets":{"deposit":"fac4b66e-8436-4d26-b189-1aa1286d2109"},"_deposit":{"id":"2011130","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2011130"},"status":"published"},"_oai":{"id":"oai:u-ryukyu.repo.nii.ac.jp:02011130","sets":["1642838163960:1642838338003","1642838403551:1642838407795"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_1551255647225":"A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations","subitem_1551255648112":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naka, I","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hikami, K","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakayama, K","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Koga, M","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishida, N","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kimura, R","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Furusawa, T","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Natsuhara, K","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamauchi, T","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakazawa, M","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ataka, Y","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishida, T","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inaoka, T","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwamoto, S","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsumura, Y","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohtsuka, R","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsuchiya, N","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohashi, J","creatorNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_1522299639480":"open access","subitem_1600958577026":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_1522650717957":"en","subitem_1522651041219":"Creative Commons Attribution-NonCommercial-NoDerivs 3.0"},{"subitem_1522650717957":"en","subitem_1522650727486":"https://creativecommons.org/licenses/by-nc-nd/3.0/","subitem_1522651041219":"https://creativecommons.org/licenses/by-nc-nd/3.0/"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"beta-2 adrenergic receptor gene (ADRB2)"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"body mass index (BMI)"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"obesity"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"Oceanic population"},{"subitem_1522299896455":"en","subitem_1522300014469":"Other","subitem_1523261968819":"polymorphism"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"OBJECTIVE:Obesity is a growing health concern in the Oceanic populations. To investigate the genetic factors associated with adult obesity in the Oceanic populations, the association of single nucleotide polymorphisms (SNPs) of the beta-2 adrenergic receptor (ADRB2) gene with obesity was examined in 694 adults living in Tonga and Solomon Islands.\\nRESULTS:A screening for variation in 16 Oceanic subjects detected 17 SNPs in the entire region of ADRB2, of which nine SNPs including two non-synonymous ones, rs1042713 (Arg16Gly) and rs1042714 (Gln27Glu), were further genotyped for all subjects. The rs34623097-A allele, at a SNP located upstream of ADRB2, showed the strongest association with risk for obesity in a logistic regression analysis adjusted for age, sex, and population (P=5.6 × 10^<−4>, odds ratio [OR]=2.5, 95% confidence interval [CI]=1.5–4.2). The 27Glu was also significantly associated with obesity in the single-point association analysis (P=0.013, OR=2.0, 95%CI=1.2–3.4); however, this association was no longer significant after adjustment for rs34623097 since these SNPs were in linkage disequilibrium with each other. A copy of the obesity-risk allele, rs34623097-A, led to a 1.6 kg/m^2 increase in body mass index (BMI; defined as weight in kilograms divided by height in meters squared) (P=0.0019). A luciferase reporter assay indicated that rs34623097-A reduced the transcriptional activity of the luciferase reporter gene by approximately 10% compared with rs34623097-G. An electrophoretic mobility shift assay demonstrated that rs34623097 modulated the binding affinity with nuclear factors. An evolutionary analysis implies that a G>A mutation at rs34623097 occurred in the Neandertal genome and then the rs34623097-A allele flowed into the ancestors of present-day humans.\\nCONCLUSION:The present results suggest that rs34623097-A, which would lead to lower expression of ADRB2, contributes to the onset of obesity in the Oceanic populations.","subitem_description_type":"Other"},{"subitem_description":"論文","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_1522300295150":"en","subitem_1522300316516":"Springer Nature"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_1551255818386":"eng"}]},"item_1617186783814":{"attribute_name":"Identifier","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/20.500.12000/46966"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_1522646500366":"ISSN","subitem_1522646572813":"0307-0565"},{"subitem_1522646500366":"ISSN","subitem_1522646572813":"1476-5497"}]},"item_1617186941041":{"attribute_name":"Source Title","attribute_value_mlt":[{"subitem_1522650068558":"en","subitem_1522650091861":"International Journal of Obesity"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1210","bibliographicPageStart":"1204","bibliographicVolumeNumber":"37"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_1522305645492":"VoR","subitem_1600292170262":"http://purl.org/coar/version/c_970fb48d4fbd8a85"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1038/ijo.2012.206"}},{"subitem_1522306287251":{"subitem_1522306382014":"DOI","subitem_1522306436033":"https://doi.org/10.1038/ijo.2012.206"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","filename":"ijo2012206.pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://u-ryukyu.repo.nii.ac.jp/record/2011130/files/ijo2012206.pdf"},"version_id":"6e3383ac-f4b4-4d95-b238-322681de6c96"}]},"item_title":"A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations","item_type_id":"15","owner":"1","path":["1642838338003","1642838407795"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-13"},"publish_date":"2020-10-13","publish_status":"0","recid":"2011130","relation_version_is_last":true,"title":["A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-03T05:35:08.578335+00:00"}